Torsade de pointes induced by intravenous and long-term oral amiodarone therapy in a patient with dilated cardiomyopathy

S. Yamada, K. Kuga, I. Yamaguchi

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

A 70-year-old woman with dilated cardiomyopathy and ventricular tachyarrhythmia was initially treated in 1990 with intravenous amiodarone (240mg). She developed a junctional escape rhythm (48 beats/min) with QT prolongation (QT: 0.68 s) and 8 h later developed torsade de pointes (TdP). Because other antiarrhythmic drugs did not suppress the arrhythmia, oral amiodarone (100 mg/day) was started in 1995, 7 weeks before she presented with congestive heart failure. The QT prolongation (QTc: 0.64) increased after administration of dopamine, and TdP again developed. This case suggests that amiodarone induces proarrhythmias by different mechanisms when administered intravenously or orally.

Original languageEnglish (US)
Pages (from-to)236-238
Number of pages3
JournalJapanese Circulation Journal
Volume65
Issue number3
DOIs
StatePublished - 2001

Keywords

  • Adrenergic-dependent
  • Amiodarone
  • Bradycardia-dependent
  • Dilated cardiomyopathy
  • Torsade de pointes

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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