TOR-autophagy signaling in adult zebrafish models of cardiomyopathy

Yonghe Ding, Xiaojing Sun, Xiaolei Xu

Research output: Contribution to journalShort survey

7 Scopus citations

Abstract

The target of rapamycin (TOR) kinase is part of an evolutionarily conserved signaling pathway that coordinates cell growth, survival, and autophagy. Previously, pharmacological studies using rapamycin have suggested a cardioprotective effect of TOR signaling inhibition on cardiomyopathy. We found that rapamycin exerts a conserved cardioprotective effect in two adult zebrafish models of cardiomyopathy of different etiology, and provided the first genetic evidence to support a long-term cardioprotective effect of TOR signaling inhibition. Moreover, we detected dynamic TOR-autophagy activities along different stages of cardiomyopathy. This needs to be considered when developing TOR-autophagy-based therapeutics for cardiomyopathy.

Original languageEnglish (US)
Pages (from-to)142-143
Number of pages2
JournalAutophagy
Volume8
Issue number1
DOIs
StatePublished - Jan 2012

Keywords

  • Anemia
  • Autophagy
  • Cardiomyopathy
  • Cardioprotective
  • Doxorubicin
  • Target of rapamycin
  • Zebrafish

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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