Topical tacrolimus in the treatment of symptomatic oral lichen planus

A series of 13 patients

Todd W. Rozycki, Roy S. Rogers, Mark R. Pittelkow, Marian T. McEvoy, Rokea A. El-Azhary, Alison Bruce, Joseph P. Fiore, Mark D.P. Davis

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

Background: Oral lichen planus (OLP) is a relatively common, chronic inflammatory, condition, which frequently presents with symptoms of pain and irritation. OLP is often difficult to manage. Therefore there is a need for more effective and safer therapies for symptomatic OLP. Objective: Our purpose was to determine the effectiveness of topical tacrolimus as therapy for symptomatic OLP. Methods: A retrospective review was performed of 13 patients with symptomatic OLP treated with topical tacrolimus between September 1999 and September 2000. Results: Eleven of the 13 patients reported definite symptomatic response to treatment and 2 had no response. Eight patients had a partial response, whereas 3 patients had a complete response with respect to lesion clearance. Seven of the responding patients had no flares with continued treatment. The other 4 patients noted flares soon after stopping the treatment. Side effects were rare and minor. Conclusions: In this retrospective case series of 13 patients, topical tacrolimus was well tolerated and appeared to be an effective therapy to control symptoms and clear lesions of OLP.

Original languageEnglish (US)
Pages (from-to)27-34
Number of pages8
JournalJournal of the American Academy of Dermatology
Volume46
Issue number1
DOIs
StatePublished - Jan 1 2002

Fingerprint

Oral Lichen Planus
Tacrolimus
Therapeutics
Pain

ASJC Scopus subject areas

  • Dermatology

Cite this

Rozycki, T. W., Rogers, R. S., Pittelkow, M. R., McEvoy, M. T., El-Azhary, R. A., Bruce, A., ... Davis, M. D. P. (2002). Topical tacrolimus in the treatment of symptomatic oral lichen planus: A series of 13 patients. Journal of the American Academy of Dermatology, 46(1), 27-34. https://doi.org/10.1067/mjd.2002.119648

Topical tacrolimus in the treatment of symptomatic oral lichen planus : A series of 13 patients. / Rozycki, Todd W.; Rogers, Roy S.; Pittelkow, Mark R.; McEvoy, Marian T.; El-Azhary, Rokea A.; Bruce, Alison; Fiore, Joseph P.; Davis, Mark D.P.

In: Journal of the American Academy of Dermatology, Vol. 46, No. 1, 01.01.2002, p. 27-34.

Research output: Contribution to journalArticle

Rozycki, TW, Rogers, RS, Pittelkow, MR, McEvoy, MT, El-Azhary, RA, Bruce, A, Fiore, JP & Davis, MDP 2002, 'Topical tacrolimus in the treatment of symptomatic oral lichen planus: A series of 13 patients', Journal of the American Academy of Dermatology, vol. 46, no. 1, pp. 27-34. https://doi.org/10.1067/mjd.2002.119648
Rozycki, Todd W. ; Rogers, Roy S. ; Pittelkow, Mark R. ; McEvoy, Marian T. ; El-Azhary, Rokea A. ; Bruce, Alison ; Fiore, Joseph P. ; Davis, Mark D.P. / Topical tacrolimus in the treatment of symptomatic oral lichen planus : A series of 13 patients. In: Journal of the American Academy of Dermatology. 2002 ; Vol. 46, No. 1. pp. 27-34.
@article{4aedaf1eaf7b40acbf6d5b0b226447cf,
title = "Topical tacrolimus in the treatment of symptomatic oral lichen planus: A series of 13 patients",
abstract = "Background: Oral lichen planus (OLP) is a relatively common, chronic inflammatory, condition, which frequently presents with symptoms of pain and irritation. OLP is often difficult to manage. Therefore there is a need for more effective and safer therapies for symptomatic OLP. Objective: Our purpose was to determine the effectiveness of topical tacrolimus as therapy for symptomatic OLP. Methods: A retrospective review was performed of 13 patients with symptomatic OLP treated with topical tacrolimus between September 1999 and September 2000. Results: Eleven of the 13 patients reported definite symptomatic response to treatment and 2 had no response. Eight patients had a partial response, whereas 3 patients had a complete response with respect to lesion clearance. Seven of the responding patients had no flares with continued treatment. The other 4 patients noted flares soon after stopping the treatment. Side effects were rare and minor. Conclusions: In this retrospective case series of 13 patients, topical tacrolimus was well tolerated and appeared to be an effective therapy to control symptoms and clear lesions of OLP.",
author = "Rozycki, {Todd W.} and Rogers, {Roy S.} and Pittelkow, {Mark R.} and McEvoy, {Marian T.} and El-Azhary, {Rokea A.} and Alison Bruce and Fiore, {Joseph P.} and Davis, {Mark D.P.}",
year = "2002",
month = "1",
day = "1",
doi = "10.1067/mjd.2002.119648",
language = "English (US)",
volume = "46",
pages = "27--34",
journal = "Journal of the American Academy of Dermatology",
issn = "0190-9622",
publisher = "Mosby Inc.",
number = "1",

}

TY - JOUR

T1 - Topical tacrolimus in the treatment of symptomatic oral lichen planus

T2 - A series of 13 patients

AU - Rozycki, Todd W.

AU - Rogers, Roy S.

AU - Pittelkow, Mark R.

AU - McEvoy, Marian T.

AU - El-Azhary, Rokea A.

AU - Bruce, Alison

AU - Fiore, Joseph P.

AU - Davis, Mark D.P.

PY - 2002/1/1

Y1 - 2002/1/1

N2 - Background: Oral lichen planus (OLP) is a relatively common, chronic inflammatory, condition, which frequently presents with symptoms of pain and irritation. OLP is often difficult to manage. Therefore there is a need for more effective and safer therapies for symptomatic OLP. Objective: Our purpose was to determine the effectiveness of topical tacrolimus as therapy for symptomatic OLP. Methods: A retrospective review was performed of 13 patients with symptomatic OLP treated with topical tacrolimus between September 1999 and September 2000. Results: Eleven of the 13 patients reported definite symptomatic response to treatment and 2 had no response. Eight patients had a partial response, whereas 3 patients had a complete response with respect to lesion clearance. Seven of the responding patients had no flares with continued treatment. The other 4 patients noted flares soon after stopping the treatment. Side effects were rare and minor. Conclusions: In this retrospective case series of 13 patients, topical tacrolimus was well tolerated and appeared to be an effective therapy to control symptoms and clear lesions of OLP.

AB - Background: Oral lichen planus (OLP) is a relatively common, chronic inflammatory, condition, which frequently presents with symptoms of pain and irritation. OLP is often difficult to manage. Therefore there is a need for more effective and safer therapies for symptomatic OLP. Objective: Our purpose was to determine the effectiveness of topical tacrolimus as therapy for symptomatic OLP. Methods: A retrospective review was performed of 13 patients with symptomatic OLP treated with topical tacrolimus between September 1999 and September 2000. Results: Eleven of the 13 patients reported definite symptomatic response to treatment and 2 had no response. Eight patients had a partial response, whereas 3 patients had a complete response with respect to lesion clearance. Seven of the responding patients had no flares with continued treatment. The other 4 patients noted flares soon after stopping the treatment. Side effects were rare and minor. Conclusions: In this retrospective case series of 13 patients, topical tacrolimus was well tolerated and appeared to be an effective therapy to control symptoms and clear lesions of OLP.

UR - http://www.scopus.com/inward/record.url?scp=0036149218&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036149218&partnerID=8YFLogxK

U2 - 10.1067/mjd.2002.119648

DO - 10.1067/mjd.2002.119648

M3 - Article

VL - 46

SP - 27

EP - 34

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

SN - 0190-9622

IS - 1

ER -