TY - JOUR
T1 - Topical Mitomycin C application in the treatment of refractory benign esophageal strictures in adults and comprehensive literature review
AU - Bartel, Michael J.
AU - Seeger, Kristina
AU - Jeffers, Kayin
AU - Clayton, Donnesha
AU - Wallace, Michael B.
AU - Raimondo, Massimo
AU - Woodward, Timothy A.
N1 - Publisher Copyright:
© 2016 Editrice Gastroenterologica Italiana S.r.l.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Background Recurrent complex esophageal strictures remain difficult to manage. Aims To determine the efficacy of topical Mitomycin C application for recurrent benign esophageal strictures. Methods All patients who underwent balloon dilation followed by topical Mitomycin C application for recurrent benign esophageal strictures were included. Primary outcome was number of dilations and change of dysphagia score. Results Nine patients with anastomotic (3), radiation-induced (3), caustic (2), and combined anastomotic and radiation-induced (1) strictures were included. Strictures had a mean length of 13.75 mm, diameter of 8.0 mm, and were dilated 10.7 times over a median of 8 months (1.5 dilations per month). Following Mitomycin C application, the need for further dilation decreased to 0.39 dilations per month over a median of 10 months; however, dysphagia scores improved not significantly from 3.2 to 2.6 (mean). Conclusion In this pilot study, topical Mitomycin C in conjunction with dilation decreased the frequency of esophageal dilations for recurrent benign esophageal strictures.
AB - Background Recurrent complex esophageal strictures remain difficult to manage. Aims To determine the efficacy of topical Mitomycin C application for recurrent benign esophageal strictures. Methods All patients who underwent balloon dilation followed by topical Mitomycin C application for recurrent benign esophageal strictures were included. Primary outcome was number of dilations and change of dysphagia score. Results Nine patients with anastomotic (3), radiation-induced (3), caustic (2), and combined anastomotic and radiation-induced (1) strictures were included. Strictures had a mean length of 13.75 mm, diameter of 8.0 mm, and were dilated 10.7 times over a median of 8 months (1.5 dilations per month). Following Mitomycin C application, the need for further dilation decreased to 0.39 dilations per month over a median of 10 months; however, dysphagia scores improved not significantly from 3.2 to 2.6 (mean). Conclusion In this pilot study, topical Mitomycin C in conjunction with dilation decreased the frequency of esophageal dilations for recurrent benign esophageal strictures.
KW - Benign esophageal strictures
KW - Complex
KW - Mitomycin C
KW - Treatment outcome
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U2 - 10.1016/j.dld.2016.06.024
DO - 10.1016/j.dld.2016.06.024
M3 - Article
C2 - 27443493
AN - SCOPUS:84978811147
SN - 1590-8658
VL - 48
SP - 1058
EP - 1065
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
IS - 9
ER -