Topical Mitomycin C application in the treatment of refractory benign esophageal strictures in adults and comprehensive literature review

Michael J. Bartel, Kristina Seeger, Kayin Jeffers, Donnesha Clayton, Michael B. Wallace, Massimo Raimondo, Timothy A. Woodward

Research output: Contribution to journalArticle

5 Scopus citations


Background: Recurrent complex esophageal strictures remain difficult to manage. Aims: To determine the efficacy of topical Mitomycin C application for recurrent benign esophageal strictures. Methods: All patients who underwent balloon dilation followed by topical Mitomycin C application for recurrent benign esophageal strictures were included. Primary outcome was number of dilations and change of dysphagia score. Results: Nine patients with anastomotic (3), radiation-induced (3), caustic (2), and combined anastomotic and radiation-induced (1) strictures were included. Strictures had a mean length of 13.75. mm, diameter of 8.0. mm, and were dilated 10.7 times over a median of 8 months (1.5 dilations per month). Following Mitomycin C application, the need for further dilation decreased to 0.39 dilations per month over a median of 10 months; however, dysphagia scores improved not significantly from 3.2 to 2.6 (mean). Conclusion: In this pilot study, topical Mitomycin C in conjunction with dilation decreased the frequency of esophageal dilations for recurrent benign esophageal strictures.

Original languageEnglish (US)
JournalDigestive and Liver Disease
StateAccepted/In press - Apr 13 2016



  • Benign esophageal strictures
  • Complex
  • Mitomycin C
  • Treatment outcome

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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