Topical drug delivery in humans with a single photomechanical wave

Shun Lee, Nikiforos Kollias, Daniel J. McAuliffe, Thomas J. Flotte, Apostolos G. Doukas

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

Purpose. Assess the feasibility of in vivo topical drug delivery in humans with a single photomechanical wave. Methods. Photomechanical waves were generated with a 23 nsec Q-switched ruby laser. In vivo fluorescence spectroscopy was used as an elegant non-invasive assay of transport of 5- aminolevulinic acid into the skin following the application of a single photomechanical wave. Results. The barrier function of the human stratum corneum in vivo may be modulated by a single (11 0 nsec) photomechanical compression wave without adversely affecting the viability and structure of the epidermis and dermis. Furthermore, the stratum corneum barrier always recovers within minutes following a photomechanical wave. The application of the photomechanical wave did not cause any pain. The dose delivered across the stratum corneum depends on the peak pressure and has a threshold at ~ 350 bar. A 30% increase in peak pressure, produced a 680% increase in the amount delivered. Conclusions. Photomechanical waves may have important implications for transcutaneous drug delivery.

Original languageEnglish (US)
Pages (from-to)1717-1721
Number of pages5
JournalPharmaceutical research
Volume16
Issue number11
DOIs
StatePublished - Nov 22 1999

Keywords

  • 5-aminolevulinic acid
  • Photoacoustics
  • Ruby laser
  • Shock waves
  • Stress waves
  • Transdermal drug delivery

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry
  • Pharmacology (medical)

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