Toll-deficient Drosophila are resistant to infection by Pneumocystis spp. additional evidence of specificity to mammalian hosts

Scott E. Evans; Konstantinos Leventakos; Ronen Ben-Ami; Dahui You; Sachin G. Thakkar; Russell E. Lewis; Dimitrios P. Kontoyiannis

doi:10.4161/viru.1.6.13903

Toll-deficient Drosophila are resistant to infection by Pneumocystis spp. additional evidence of specificity to mammalian hosts

Scott E. Evans, Konstantinos Leventakos, Ronen Ben-Ami, Dahui You, Sachin G. Thakkar, Russell E. Lewis, Dimitrios P. Kontoyiannis

Oncology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Pneumocystis spp. are significant pathogens in a variety of mammals. We tried to establish a Drosophila model of pneumocystosis using either P. murina or P. carinii. Whereas the pathogens were competent in susceptible mice, no infection could be established even in corticosteroid-treated Toll-deficient flies. This further substantiates the tropism described for mammalian hosts.

Original language	English (US)
Pages (from-to)	523-525
Number of pages	3
Journal	Virulence
Volume	1
Issue number	6
DOIs	https://doi.org/10.4161/viru.1.6.13903
State	Published - Jul 2010

Keywords

Drosophila melanogaster
Fungal pathogen
Mini host model
Pneumocystis spp.

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Microbiology (medical)
Infectious Diseases

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10.4161/viru.1.6.13903

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abstract = "Pneumocystis spp. are significant pathogens in a variety of mammals. We tried to establish a Drosophila model of pneumocystosis using either P. murina or P. carinii. Whereas the pathogens were competent in susceptible mice, no infection could be established even in corticosteroid-treated Toll-deficient flies. This further substantiates the tropism described for mammalian hosts.",

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AU - Evans, Scott E.

AU - Leventakos, Konstantinos

AU - Ben-Ami, Ronen

AU - You, Dahui

AU - Thakkar, Sachin G.

AU - Lewis, Russell E.

AU - Kontoyiannis, Dimitrios P.

PY - 2010/7

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AB - Pneumocystis spp. are significant pathogens in a variety of mammals. We tried to establish a Drosophila model of pneumocystosis using either P. murina or P. carinii. Whereas the pathogens were competent in susceptible mice, no infection could be established even in corticosteroid-treated Toll-deficient flies. This further substantiates the tropism described for mammalian hosts.

KW - Drosophila melanogaster

KW - Fungal pathogen

KW - Mini host model

KW - Pneumocystis spp.

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ER -

Toll-deficient Drosophila are resistant to infection by Pneumocystis spp. additional evidence of specificity to mammalian hosts

Abstract

Keywords

ASJC Scopus subject areas

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