Toll-deficient Drosophila are resistant to infection by Pneumocystis spp. additional evidence of specificity to mammalian hosts

Scott E. Evans, Konstantinos Leventakos, Ronen Ben-Ami, Dahui You, Sachin G. Thakkar, Russell E. Lewis, Dimitrios P. Kontoyiannis

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Pneumocystis spp. are significant pathogens in a variety of mammals. We tried to establish a Drosophila model of pneumocystosis using either P. murina or P. carinii. Whereas the pathogens were competent in susceptible mice, no infection could be established even in corticosteroid-treated Toll-deficient flies. This further substantiates the tropism described for mammalian hosts.

Original languageEnglish (US)
Pages (from-to)523-525
Number of pages3
JournalVirulence
Volume1
Issue number6
DOIs
StatePublished - Jul 2010

Keywords

  • Drosophila melanogaster
  • Fungal pathogen
  • Mini host model
  • Pneumocystis spp.

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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