Toll and interleukin-1 receptor (TIR) domain-containing proteins in plants: A genomic perspective

Judith A. Jebanathirajah, Suraj Peri, Akhilesh Pandey

Research output: Contribution to journalReview article

35 Scopus citations


Toll and interleukin-1 receptor (TIR) domains were originally described from comparisons of proteins found in mammals and Drosophila. They are now known to occur in several organisms, with the most TIR proteins being found in Arabidopsis: our analysis of the sequenced Arabidopsis genome has revealed the presence of at least 135 proteins containing TIR domains. Several novel types of TIR-domain-containing proteins are found in Arabidopsis that are not found in other genomes. Here, we discuss the roles of TIR-domain-containing proteins in pathogen resistance and as candidate signaling modules.

Original languageEnglish (US)
Pages (from-to)388-391
Number of pages4
JournalTrends in Plant Science
Issue number9
StatePublished - Sep 1 2002


ASJC Scopus subject areas

  • Plant Science

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