Tolerance to morphine-induced mydriasis in the rat pupil

Charles Howard Adler, Michael Robin, Martin W. Adler

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Despite the commonly held view that tolerance does not develop to the pupillary effects of narcotics, recent studies have demonstrated tolerance to heroin-induced miosis in humans and to morphine-induced mydriasis in the mouse. Previous studies in this laboratory have shown that morphine produces a dose-related mydriasis and fluctuation (large amplitude, irregular oscillations in pupil diameter) in the rat pupil; the present study was designed to determine if tolerance develops to these effects following subcutaneous implantation of morphine pellets. We found that there is, indeed, tolerance to the morphine-induced mydriasis, but it is not complete. Furthermore, statistically significant tolerance does not develop to morphine-induced fluctuations in the rat pupil.

Original languageEnglish (US)
Pages (from-to)2469-2475
Number of pages7
JournalLife Sciences
Volume28
Issue number22
DOIs
StatePublished - Jun 1 1981
Externally publishedYes

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Mydriasis
Pupil
Morphine
Rats
Miosis
Narcotics
Heroin

ASJC Scopus subject areas

  • Pharmacology

Cite this

Tolerance to morphine-induced mydriasis in the rat pupil. / Adler, Charles Howard; Robin, Michael; Adler, Martin W.

In: Life Sciences, Vol. 28, No. 22, 01.06.1981, p. 2469-2475.

Research output: Contribution to journalArticle

Adler, Charles Howard ; Robin, Michael ; Adler, Martin W. / Tolerance to morphine-induced mydriasis in the rat pupil. In: Life Sciences. 1981 ; Vol. 28, No. 22. pp. 2469-2475.
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