TNF inhibits insulin induced STAT5 activation in differentiated mouse muscle cells pmi28

Peter Storz, Heike Döppler, Anton Wernig, Klaus Pfizenmaier, Gertraud Müller

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Tumor necrosis factor (TNF) plays a central role in the state of insulin resistance leading to type II diabetes. We here describe the crosstalk of TNF with insulin signaling cascades in the mouse muscle cell line pmi28. TNF downregulated insulin induced insulin receptor kinase activity and insulin induced activation of the transcription factor STAT5. Our results provide evidence that the inhibitory crosstalk between TNF and insulin in skeletal muscle cells comprises an interference with the expression of STAT5 regulated genes which may play an important role in the manifestation and/or progression of insulin resistance in muscle cells. Copyright (C) 1998 Federation of European Biochemical Societies.

Original languageEnglish (US)
Pages (from-to)41-45
Number of pages5
JournalFEBS Letters
Volume440
Issue number1-2
DOIs
StatePublished - Nov 27 1998

Keywords

  • Insulin resistance
  • STAT5
  • Skeletal muscle
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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