TNF inhibits insulin induced STAT5 activation in differentiated mouse muscle cells pmi28

Peter Storz; Heike Döppler; Anton Wernig; Klaus Pfizenmaier; Gertraud Müller

doi:10.1016/S0014-5793(98)01421-5

TNF inhibits insulin induced STAT5 activation in differentiated mouse muscle cells pmi28

Peter Storz, Heike Döppler, Anton Wernig, Klaus Pfizenmaier, Gertraud Müller

Cancer Biology

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Tumor necrosis factor (TNF) plays a central role in the state of insulin resistance leading to type II diabetes. We here describe the crosstalk of TNF with insulin signaling cascades in the mouse muscle cell line pmi28. TNF downregulated insulin induced insulin receptor kinase activity and insulin induced activation of the transcription factor STAT5. Our results provide evidence that the inhibitory crosstalk between TNF and insulin in skeletal muscle cells comprises an interference with the expression of STAT5 regulated genes which may play an important role in the manifestation and/or progression of insulin resistance in muscle cells. Copyright (C) 1998 Federation of European Biochemical Societies.

Original language	English (US)
Pages (from-to)	41-45
Number of pages	5
Journal	FEBS Letters
Volume	440
Issue number	1-2
DOIs	https://doi.org/10.1016/S0014-5793(98)01421-5
State	Published - Nov 27 1998

Keywords

Insulin resistance
STAT5
Skeletal muscle
Tumor necrosis factor

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/S0014-5793(98)01421-5

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title = "TNF inhibits insulin induced STAT5 activation in differentiated mouse muscle cells pmi28",

abstract = "Tumor necrosis factor (TNF) plays a central role in the state of insulin resistance leading to type II diabetes. We here describe the crosstalk of TNF with insulin signaling cascades in the mouse muscle cell line pmi28. TNF downregulated insulin induced insulin receptor kinase activity and insulin induced activation of the transcription factor STAT5. Our results provide evidence that the inhibitory crosstalk between TNF and insulin in skeletal muscle cells comprises an interference with the expression of STAT5 regulated genes which may play an important role in the manifestation and/or progression of insulin resistance in muscle cells. Copyright (C) 1998 Federation of European Biochemical Societies.",

keywords = "Insulin resistance, STAT5, Skeletal muscle, Tumor necrosis factor",

author = "Peter Storz and Heike D{\"o}ppler and Anton Wernig and Klaus Pfizenmaier and Gertraud M{\"u}ller",

note = "Funding Information: We want to thank Prof. A. Starzinski-Powitz for the monoclonal antibody MF-20. This work was supported by Boehringer Ingelheim KG, Grant B.3.10.E from the Bundesministerium f{\"u}r Bildung, Wissenschaft, Forschung und Technologie, Germany, and DFG Grant Mu625/5. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.",

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T1 - TNF inhibits insulin induced STAT5 activation in differentiated mouse muscle cells pmi28

AU - Storz, Peter

AU - Döppler, Heike

AU - Wernig, Anton

AU - Pfizenmaier, Klaus

AU - Müller, Gertraud

N1 - Funding Information: We want to thank Prof. A. Starzinski-Powitz for the monoclonal antibody MF-20. This work was supported by Boehringer Ingelheim KG, Grant B.3.10.E from the Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie, Germany, and DFG Grant Mu625/5. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.

PY - 1998/11/27

Y1 - 1998/11/27

N2 - Tumor necrosis factor (TNF) plays a central role in the state of insulin resistance leading to type II diabetes. We here describe the crosstalk of TNF with insulin signaling cascades in the mouse muscle cell line pmi28. TNF downregulated insulin induced insulin receptor kinase activity and insulin induced activation of the transcription factor STAT5. Our results provide evidence that the inhibitory crosstalk between TNF and insulin in skeletal muscle cells comprises an interference with the expression of STAT5 regulated genes which may play an important role in the manifestation and/or progression of insulin resistance in muscle cells. Copyright (C) 1998 Federation of European Biochemical Societies.

AB - Tumor necrosis factor (TNF) plays a central role in the state of insulin resistance leading to type II diabetes. We here describe the crosstalk of TNF with insulin signaling cascades in the mouse muscle cell line pmi28. TNF downregulated insulin induced insulin receptor kinase activity and insulin induced activation of the transcription factor STAT5. Our results provide evidence that the inhibitory crosstalk between TNF and insulin in skeletal muscle cells comprises an interference with the expression of STAT5 regulated genes which may play an important role in the manifestation and/or progression of insulin resistance in muscle cells. Copyright (C) 1998 Federation of European Biochemical Societies.

KW - Insulin resistance

KW - STAT5

KW - Skeletal muscle

KW - Tumor necrosis factor

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TNF inhibits insulin induced STAT5 activation in differentiated mouse muscle cells pmi28

Abstract

Keywords

ASJC Scopus subject areas

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