Tissue-resident CD4+ T helper cells assist the development of protective respiratory B and CD8+ T cell memory responses

Young Min Son, In Su Cheon, Yue Wu, Chaofan Li, Zheng Wang, Xiaochen Gao, Yao Chen, Yoshimasa Takahashi, Yang Xin Fu, Alexander L. Dent, Mark H. Kaplan, Justin J. Taylor, Weiguo Cui, Jie Sun

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Much remains unknown about the roles of CD4+ T helper cells in shaping localized memory B cell and CD8+ T cell immunity in the mucosal tissues. Here, we report that lung T helper cells provide local assistance for the optimal development of tissue-resident memory B and CD8+ T cells after the resolution of primary influenza virus infection. We have identified a population of T cells in the lung that exhibit characteristics of both follicular T helper and TRM cells, and we have termed these cells as resident helper T (TRH) cells. Optimal TRH cell formation was dependent on transcription factors involved in T follicular helper and resident memory T cell development including BCL6 and Bhlhe40. We show that TRH cells deliver local help to CD8+ T cells through IL-21-dependent mechanisms. Our data have uncovered the presence of a tissue-resident helper T cell population in the lung that plays a critical role in promoting the development of protective B cell and CD8+ T cell responses.

Original languageEnglish (US)
Article numbereabb6852
JournalScience Immunology
Volume6
Issue number55
DOIs
StatePublished - Jan 2021

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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