Tissue methylated DNA markers for sporadic pancreatic cancer are strongly associated with familial and genetically predisposed pancreatic cancer

Shounak Majumder; William R. Taylor; Patrick H. Foote; Brianna J. Gysbers; Xiaoming Cao; Douglas W. Mahoney; Kelli N. Burger; Karen A. Doering; Rondell P. Graham; Fergus J. Couch; Gloria M. Petersen; John B. Kisiel

doi:10.1016/j.pan.2022.06.259

Tissue methylated DNA markers for sporadic pancreatic cancer are strongly associated with familial and genetically predisposed pancreatic cancer

Shounak Majumder, William R. Taylor, Patrick H. Foote, Brianna J. Gysbers, Xiaoming Cao, Douglas W. Mahoney, Kelli N. Burger, Karen A. Doering, Rondell P. Graham, Fergus J. Couch, Gloria M. Petersen, John B. Kisiel

Research output: Contribution to journal › Article › peer-review

Abstract

High-risk individuals (HRIs) with familial and genetic predisposition to pancreatic ductal adenocarcinoma (PDAC) are eligible for screening. There is no accurate biomarker for detecting early-stage PDAC. We previously demonstrated that a panel of methylated DNA markers (MDMs) accurately detect sporadic PDAC. In this study we compared the distribution of MDMs in DNA extracted from tissue of PDAC cases who carry germline mutations and non-carriers with family history, with control tissue and demonstrate high discrimination like that seen in sporadic PDAC. These results provide scientific rationale for examining plasma MDMs in HRIs with the goal of developing a minimally-invasive early detection test.

Original language	English (US)
Journal	Pancreatology
DOIs	https://doi.org/10.1016/j.pan.2022.06.259
State	Accepted/In press - 2022

Keywords

Biomarker
DNA methylation
Pancreatic cancer

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism
Hepatology

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10.1016/j.pan.2022.06.259

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Majumder, S., Taylor, W. R., Foote, P. H., Gysbers, B. J., Cao, X., Mahoney, D. W., Burger, K. N., Doering, K. A., Graham, R. P., Couch, F. J., Petersen, G. M., & Kisiel, J. B. (Accepted/In press). Tissue methylated DNA markers for sporadic pancreatic cancer are strongly associated with familial and genetically predisposed pancreatic cancer. Pancreatology. https://doi.org/10.1016/j.pan.2022.06.259

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title = "Tissue methylated DNA markers for sporadic pancreatic cancer are strongly associated with familial and genetically predisposed pancreatic cancer",

abstract = "High-risk individuals (HRIs) with familial and genetic predisposition to pancreatic ductal adenocarcinoma (PDAC) are eligible for screening. There is no accurate biomarker for detecting early-stage PDAC. We previously demonstrated that a panel of methylated DNA markers (MDMs) accurately detect sporadic PDAC. In this study we compared the distribution of MDMs in DNA extracted from tissue of PDAC cases who carry germline mutations and non-carriers with family history, with control tissue and demonstrate high discrimination like that seen in sporadic PDAC. These results provide scientific rationale for examining plasma MDMs in HRIs with the goal of developing a minimally-invasive early detection test.",

keywords = "Biomarker, DNA methylation, Pancreatic cancer",

author = "Shounak Majumder and Taylor, {William R.} and Foote, {Patrick H.} and Gysbers, {Brianna J.} and Xiaoming Cao and Mahoney, {Douglas W.} and Burger, {Kelli N.} and Doering, {Karen A.} and Graham, {Rondell P.} and Couch, {Fergus J.} and Petersen, {Gloria M.} and Kisiel, {John B.}",

note = "Publisher Copyright: {\textcopyright} 2022",

year = "2022",

doi = "10.1016/j.pan.2022.06.259",

language = "English (US)",

journal = "Pancreatology",

issn = "1424-3903",

publisher = "S. Karger AG",

}

TY - JOUR

T1 - Tissue methylated DNA markers for sporadic pancreatic cancer are strongly associated with familial and genetically predisposed pancreatic cancer

AU - Majumder, Shounak

AU - Taylor, William R.

AU - Foote, Patrick H.

AU - Gysbers, Brianna J.

AU - Cao, Xiaoming

AU - Mahoney, Douglas W.

AU - Burger, Kelli N.

AU - Doering, Karen A.

AU - Graham, Rondell P.

AU - Couch, Fergus J.

AU - Petersen, Gloria M.

AU - Kisiel, John B.

PY - 2022

Y1 - 2022

N2 - High-risk individuals (HRIs) with familial and genetic predisposition to pancreatic ductal adenocarcinoma (PDAC) are eligible for screening. There is no accurate biomarker for detecting early-stage PDAC. We previously demonstrated that a panel of methylated DNA markers (MDMs) accurately detect sporadic PDAC. In this study we compared the distribution of MDMs in DNA extracted from tissue of PDAC cases who carry germline mutations and non-carriers with family history, with control tissue and demonstrate high discrimination like that seen in sporadic PDAC. These results provide scientific rationale for examining plasma MDMs in HRIs with the goal of developing a minimally-invasive early detection test.

AB - High-risk individuals (HRIs) with familial and genetic predisposition to pancreatic ductal adenocarcinoma (PDAC) are eligible for screening. There is no accurate biomarker for detecting early-stage PDAC. We previously demonstrated that a panel of methylated DNA markers (MDMs) accurately detect sporadic PDAC. In this study we compared the distribution of MDMs in DNA extracted from tissue of PDAC cases who carry germline mutations and non-carriers with family history, with control tissue and demonstrate high discrimination like that seen in sporadic PDAC. These results provide scientific rationale for examining plasma MDMs in HRIs with the goal of developing a minimally-invasive early detection test.

KW - Biomarker

KW - DNA methylation

KW - Pancreatic cancer

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UR - http://www.scopus.com/inward/citedby.url?scp=85134565725&partnerID=8YFLogxK

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DO - 10.1016/j.pan.2022.06.259

M3 - Article

C2 - 35843766

AN - SCOPUS:85134565725

SN - 1424-3903

JO - Pancreatology

JF - Pancreatology

ER -

Tissue methylated DNA markers for sporadic pancreatic cancer are strongly associated with familial and genetically predisposed pancreatic cancer

Abstract

Keywords

ASJC Scopus subject areas

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