Tissue Engineering of Bone

Steven Van Gaalen, Moyo Kruyt, Gert Meijer, Amit Mistry, Antonios Mikos, Jeroen van den Beucken, John Jansen, Klaas De Groot, Ranieri Cancedda, Christina Olivo, Michael Yaszemski, Wouter Dhert

Research output: Chapter in Book/Report/Conference proceedingChapter

27 Scopus citations

Abstract

This chapter illustrates the different types and functions of bone. It summarizes the different steps in bone tissue engineering and components of a bone tissue engineering graft. Bone serves a main biomechanical function with excellent tensile and loading strength, and is involved in calcium metabolism and hematopoiesis. Currently, the most optimal bone graft is cancellous autograft bone with osteoconductive, osteoinductive and, to some extent, osteogenic qualities. Some of its drawbacks are limited supply, longer surgical procedures to obtain the graft, and concomitant complications. These drawbacks and financial reasons have boosted research into alternative bone grafts. The chapter also states that a scaffold for bone tissue engineering should ideally match the mechanical properties of the bone. It replaces and participates in the natural remodeling process, which means that it should be resorbable.

Original languageEnglish (US)
Title of host publicationTissue Engineering
PublisherElsevier Inc.
Pages559-610
Number of pages52
ISBN (Print)9780123708694
DOIs
StatePublished - 2008

ASJC Scopus subject areas

  • Engineering(all)

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    Van Gaalen, S., Kruyt, M., Meijer, G., Mistry, A., Mikos, A., Beucken, J. V. D., Jansen, J., De Groot, K., Cancedda, R., Olivo, C., Yaszemski, M., & Dhert, W. (2008). Tissue Engineering of Bone. In Tissue Engineering (pp. 559-610). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-370869-4.00019-7