Tissue characterization of coronary plaques using intravascular ultrasound/virtual histology

Jang Ho Bae, Charanjit S. Rihal, Amir Lerman

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Most studies related with plaque histopathology and/or morphology are based on the gray scale intravascular ultrasound (IVUS) and autopsy findings, although IVUS is limited for differentiating echolucent areas, and tissue shrinkage almost always occur during tissue fixation. In addition, autopsy studies can not establish the causal relationship between the autopsy findings and the clinical findings. Spectral analysis of the IVUS radiofrequency data may be a new and useful tool because it allows detailed assessment of plaque composition in vivo, with a high predictive accuracy of 87.1% to 96.5% in fibrous, fibrofatty, calcified and necrotic core regions with performing tissue mapping and geometric assessment like that for classic gray scale IVUS. This new imaging technique offers clear benefits compared with the results of classic IVUS and autopsy studies. This review will briefly discuss the methodology of spectral analysis of the IVUS radiofrequency data, the recent clinical studies that have used this technique and the future perspectives.

Original languageEnglish (US)
Pages (from-to)553-558
Number of pages6
JournalKorean Circulation Journal
Issue number8
StatePublished - Aug 2006


  • Coronary arteriosclerosis
  • Diagnostic imaging
  • Intravascular ultrasonography
  • Plaque

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine


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