Synthetic and biologic tissue glues have been used for control of bleeding and closure of fistulas and anastomotic leaks. GI endoscopic applications of cyanoacrylate and fibrin glues are considered "off-label" uses. Embolization and death have been reported with cyanoacrylate injection for hemostasis. Embolization also can occur from intravascular injection of thrombin or fibrin glue. Fibrin glue/thrombin can induce antibody formation with subsequent coagulopathy; however, this is a rare event with use of human-source blood products. There are insufficient data to support routine endoscopic use of the available preparations of cyanoacrylate, fibrin glue, and thrombin in clinical practice.
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging