Timely reconstitution of immune competence affects clinical outcome following autologous stem cell transplantation

L. F. Porrata; S. N. Markovic

doi:10.1007/s10238-004-0041-4

Timely reconstitution of immune competence affects clinical outcome following autologous stem cell transplantation

L. F. Porrata, S. N. Markovic

Hematology

Research output: Contribution to journal › Review article › peer-review

55 Scopus citations

Abstract

The anti-tumor activity of the immune system in the setting of hematopoietic stem cell transplantation has largely been described in the context of the "graft-versus-tumor" effect of allogeneic stem cell transplantation. This article reviews clinical evidence suggesting the existence of an autologous graft-versus-tumor effect in the setting of host immune system recovery following autologous stem cell transplantation resulting in prolongation of survival of cancer patients.

Original language	English (US)
Pages (from-to)	78-85
Number of pages	8
Journal	Clinical and Experimental Medicine
Volume	4
Issue number	2
DOIs	https://doi.org/10.1007/s10238-004-0041-4
State	Published - Apr 1 2004

Keywords

Absolute lymphocyte count
Autologous stem cell transplantation
Clinical outcome
Kinetics
Natural killer cells

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/s10238-004-0041-4

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AU - Markovic, S. N.

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N2 - The anti-tumor activity of the immune system in the setting of hematopoietic stem cell transplantation has largely been described in the context of the "graft-versus-tumor" effect of allogeneic stem cell transplantation. This article reviews clinical evidence suggesting the existence of an autologous graft-versus-tumor effect in the setting of host immune system recovery following autologous stem cell transplantation resulting in prolongation of survival of cancer patients.

AB - The anti-tumor activity of the immune system in the setting of hematopoietic stem cell transplantation has largely been described in the context of the "graft-versus-tumor" effect of allogeneic stem cell transplantation. This article reviews clinical evidence suggesting the existence of an autologous graft-versus-tumor effect in the setting of host immune system recovery following autologous stem cell transplantation resulting in prolongation of survival of cancer patients.

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KW - Autologous stem cell transplantation

KW - Clinical outcome

KW - Kinetics

KW - Natural killer cells

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Timely reconstitution of immune competence affects clinical outcome following autologous stem cell transplantation

Abstract

Keywords

ASJC Scopus subject areas

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