Timely reconstitution of immune competence affects clinical outcome following autologous stem cell transplantation

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Abstract

The anti-tumor activity of the immune system in the setting of hematopoietic stem cell transplantation has largely been described in the context of the "graft-versus-tumor" effect of allogeneic stem cell transplantation. This article reviews clinical evidence suggesting the existence of an autologous graft-versus-tumor effect in the setting of host immune system recovery following autologous stem cell transplantation resulting in prolongation of survival of cancer patients.

Original languageEnglish (US)
Pages (from-to)78-85
Number of pages8
JournalClinical and Experimental Medicine
Volume4
Issue number2
DOIs
StatePublished - Apr 2004

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Clinical Competence
Stem Cell Transplantation
Stem cells
Tumors
Immune system
Grafts
Transplantation (surgical)
Immune System
Neoplasms
Transplants
Hematopoietic Stem Cell Transplantation
Recovery
Survival

Keywords

  • Absolute lymphocyte count
  • Autologous stem cell transplantation
  • Clinical outcome
  • Kinetics
  • Natural killer cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Clinical Biochemistry
  • Medicine(all)

Cite this

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KW - Clinical outcome

KW - Kinetics

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