Time trends in epidemiology and characteristics of psoriatic arthritis over 3 decades

A population-based study

Floranne C. Wilson, Murat Icen, Cynthia Crowson, Marian T. McEvoy, Sherine E. Gabriel, Hilal D Maradit Kremers

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Objective. To determine time trends in incidence, prevalence, and clinical characteristics of psoriatic arthritis (PsA) over a 30-year period. Methods. We identified a population-based incidence cohort of subjects aged 18 years or over who fulfilled ClASsification of Psoriatic ARthritis (CASPAR) criteria for PsA between January 1, 1970, and December 31, 1999, in Olmsted County, Minnesota, USA. PsA incidence date was defined as the diagnosis date of those who fulfilled CASPAR criteria. Age- and sex-specific incidence rates were estimated and age- and sex-adjusted to the 2000 US White population. Results. The PsA incidence cohort comprised 147 adult subjects with a mean age of 42.7 years, and 61% were men. The overall age- and sex-adjusted annual incidence of PsA per 100,000 was 7.2 [95% confidence interval (CI) 6.0, 8.4] with a higher incidence in men (9.1, 95% CI 7.1, 11.0) than women (5.4, 95% CI 4.0, 6.9). The age- and sex-adjusted incidence of PsA per 100,000 increased from 3.6 (95% CI 2.0, 5.2) between 1970 and 1979 to 9.8 (95% CI 7.7, 11.9) between 1990 and 2000 (p for trend < 0.001). The point prevalence per 100,000 was 158 (95% CI 132, 185) in 2000, with a higher prevalence in men (193, 95% CI 150, 237) than women (127, 95% CI 94, 160). At incidence, most PsA subjects had oligoarticular involvement (49%) with enthesopathy (29%). Conclusion. The incidence of PsA has been rising over 30 years in men and women. Reasons for the increase are unknown, but may be related to a true change in incidence or greater physician awareness of the diagnosis. The Journal of Rheumatology

Original languageEnglish (US)
Pages (from-to)361-367
Number of pages7
JournalJournal of Rheumatology
Volume36
Issue number2
DOIs
StatePublished - Feb 2009

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Psoriatic Arthritis
Epidemiology
Incidence
Confidence Intervals
Population
Rheumatology

Keywords

  • Epidemiology
  • Population-based study
  • Psoriatic arthritis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Time trends in epidemiology and characteristics of psoriatic arthritis over 3 decades : A population-based study. / Wilson, Floranne C.; Icen, Murat; Crowson, Cynthia; McEvoy, Marian T.; Gabriel, Sherine E.; Maradit Kremers, Hilal D.

In: Journal of Rheumatology, Vol. 36, No. 2, 02.2009, p. 361-367.

Research output: Contribution to journalArticle

Wilson, Floranne C. ; Icen, Murat ; Crowson, Cynthia ; McEvoy, Marian T. ; Gabriel, Sherine E. ; Maradit Kremers, Hilal D. / Time trends in epidemiology and characteristics of psoriatic arthritis over 3 decades : A population-based study. In: Journal of Rheumatology. 2009 ; Vol. 36, No. 2. pp. 361-367.
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abstract = "Objective. To determine time trends in incidence, prevalence, and clinical characteristics of psoriatic arthritis (PsA) over a 30-year period. Methods. We identified a population-based incidence cohort of subjects aged 18 years or over who fulfilled ClASsification of Psoriatic ARthritis (CASPAR) criteria for PsA between January 1, 1970, and December 31, 1999, in Olmsted County, Minnesota, USA. PsA incidence date was defined as the diagnosis date of those who fulfilled CASPAR criteria. Age- and sex-specific incidence rates were estimated and age- and sex-adjusted to the 2000 US White population. Results. The PsA incidence cohort comprised 147 adult subjects with a mean age of 42.7 years, and 61{\%} were men. The overall age- and sex-adjusted annual incidence of PsA per 100,000 was 7.2 [95{\%} confidence interval (CI) 6.0, 8.4] with a higher incidence in men (9.1, 95{\%} CI 7.1, 11.0) than women (5.4, 95{\%} CI 4.0, 6.9). The age- and sex-adjusted incidence of PsA per 100,000 increased from 3.6 (95{\%} CI 2.0, 5.2) between 1970 and 1979 to 9.8 (95{\%} CI 7.7, 11.9) between 1990 and 2000 (p for trend < 0.001). The point prevalence per 100,000 was 158 (95{\%} CI 132, 185) in 2000, with a higher prevalence in men (193, 95{\%} CI 150, 237) than women (127, 95{\%} CI 94, 160). At incidence, most PsA subjects had oligoarticular involvement (49{\%}) with enthesopathy (29{\%}). Conclusion. The incidence of PsA has been rising over 30 years in men and women. Reasons for the increase are unknown, but may be related to a true change in incidence or greater physician awareness of the diagnosis. The Journal of Rheumatology",
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T1 - Time trends in epidemiology and characteristics of psoriatic arthritis over 3 decades

T2 - A population-based study

AU - Wilson, Floranne C.

AU - Icen, Murat

AU - Crowson, Cynthia

AU - McEvoy, Marian T.

AU - Gabriel, Sherine E.

AU - Maradit Kremers, Hilal D

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N2 - Objective. To determine time trends in incidence, prevalence, and clinical characteristics of psoriatic arthritis (PsA) over a 30-year period. Methods. We identified a population-based incidence cohort of subjects aged 18 years or over who fulfilled ClASsification of Psoriatic ARthritis (CASPAR) criteria for PsA between January 1, 1970, and December 31, 1999, in Olmsted County, Minnesota, USA. PsA incidence date was defined as the diagnosis date of those who fulfilled CASPAR criteria. Age- and sex-specific incidence rates were estimated and age- and sex-adjusted to the 2000 US White population. Results. The PsA incidence cohort comprised 147 adult subjects with a mean age of 42.7 years, and 61% were men. The overall age- and sex-adjusted annual incidence of PsA per 100,000 was 7.2 [95% confidence interval (CI) 6.0, 8.4] with a higher incidence in men (9.1, 95% CI 7.1, 11.0) than women (5.4, 95% CI 4.0, 6.9). The age- and sex-adjusted incidence of PsA per 100,000 increased from 3.6 (95% CI 2.0, 5.2) between 1970 and 1979 to 9.8 (95% CI 7.7, 11.9) between 1990 and 2000 (p for trend < 0.001). The point prevalence per 100,000 was 158 (95% CI 132, 185) in 2000, with a higher prevalence in men (193, 95% CI 150, 237) than women (127, 95% CI 94, 160). At incidence, most PsA subjects had oligoarticular involvement (49%) with enthesopathy (29%). Conclusion. The incidence of PsA has been rising over 30 years in men and women. Reasons for the increase are unknown, but may be related to a true change in incidence or greater physician awareness of the diagnosis. The Journal of Rheumatology

AB - Objective. To determine time trends in incidence, prevalence, and clinical characteristics of psoriatic arthritis (PsA) over a 30-year period. Methods. We identified a population-based incidence cohort of subjects aged 18 years or over who fulfilled ClASsification of Psoriatic ARthritis (CASPAR) criteria for PsA between January 1, 1970, and December 31, 1999, in Olmsted County, Minnesota, USA. PsA incidence date was defined as the diagnosis date of those who fulfilled CASPAR criteria. Age- and sex-specific incidence rates were estimated and age- and sex-adjusted to the 2000 US White population. Results. The PsA incidence cohort comprised 147 adult subjects with a mean age of 42.7 years, and 61% were men. The overall age- and sex-adjusted annual incidence of PsA per 100,000 was 7.2 [95% confidence interval (CI) 6.0, 8.4] with a higher incidence in men (9.1, 95% CI 7.1, 11.0) than women (5.4, 95% CI 4.0, 6.9). The age- and sex-adjusted incidence of PsA per 100,000 increased from 3.6 (95% CI 2.0, 5.2) between 1970 and 1979 to 9.8 (95% CI 7.7, 11.9) between 1990 and 2000 (p for trend < 0.001). The point prevalence per 100,000 was 158 (95% CI 132, 185) in 2000, with a higher prevalence in men (193, 95% CI 150, 237) than women (127, 95% CI 94, 160). At incidence, most PsA subjects had oligoarticular involvement (49%) with enthesopathy (29%). Conclusion. The incidence of PsA has been rising over 30 years in men and women. Reasons for the increase are unknown, but may be related to a true change in incidence or greater physician awareness of the diagnosis. The Journal of Rheumatology

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