Time-dependent postsynaptic AMPA GluR1 receptor recruitment in the cingulate synaptic potentiation

Hiroki Toyoda, Long Jun Wu, Ming Gao Zhao, Hui Xu, Min Zhuo

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

The anterior cingulate cortex (ACC) is critical for brain functions including learning, memory, fear and pain. Long-term synaptic potentiation (LTP), a cellular model for learning and memory, has been reported in the ACC neurons. Unlike LTP in the hippocampus and amygdala, two key structures for memory and fear, little is known about the synaptic mechanism for the expression of LTP in the ACC. Here we use whole-cell patch clamp recordings to demonstrate that cingulate LTP requires the functional recruitment of GluR1 AMPA receptors; and such events are rapid and completed within 5-10 min after LTP induction. Our results demonstrate that the GluR1 subunit is essential for synaptic plasticity in the ACC and may play critical roles under physiological and pathological conditions.

Original languageEnglish (US)
Pages (from-to)498-509
Number of pages12
JournalDevelopmental Neurobiology
Volume67
Issue number4
DOIs
StatePublished - Mar 2007

Keywords

  • AMPA receptor
  • Anterior cingulate cortex
  • Long-term potentiation
  • PDZ domain
  • Trafficking

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

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