TY - JOUR
T1 - Time delay for arrival of MR contrast agent in collateral-dependent myocardium
AU - Jerosch-Herold, Michael
AU - Hu, Xudong
AU - Murthy, Naveen S.
AU - Seethamraju, Ravi T.
N1 - Funding Information:
Manuscript received December 4, 2003; revised March 1, 2004. This work was supported by the National Institutes of Health (NIH) National Heart, Lung and Blood Institute (NHLBI) under Grant R01 HL65394-01. The Associate Editor responsible for coordinating the review of this paper and recommending its publication was G.-Z. Yang. Asterisk indicates corresponding author. *M. Jerosch-Herold is with the Department of Radiology, University of Minnesota, Minneapolis, MN 55455 USA and Oregon Health & Science University, Portland, OR 97239 USA (e-mail: jeros001@umn.edu).
PY - 2004/7
Y1 - 2004/7
N2 - An analysis of the kinetics of myocardial contrast enhancement is an important component of myocardial perfusion studies. The contrast enhancement can be modeled by a linear time-invariant system, and the myocardial impulse response, calculated by deconvolution of the measured tissue response with an arterial input, gives a direct estimate of myocardial blood flow. In this paper, we analyze the effects of delays in the contrast enhancement, that occur in collateral-dependent myocardium, where the tracer reaches the tissue region only through branches from other coronary arteries that form natural bypass vessels. We investigate how the delayed arrival of tracer alters the myocardial impulse response. Model-independent deconvolution is applied to determine the lag between arterial input and tissue enhancement. Experimental data in a porcine model of collateral development indicate that the delayed arrival of an injected tracer, measured at rest, is a useful marker to identify collateral-dependent myocardium, and predict its flow capacitance.
AB - An analysis of the kinetics of myocardial contrast enhancement is an important component of myocardial perfusion studies. The contrast enhancement can be modeled by a linear time-invariant system, and the myocardial impulse response, calculated by deconvolution of the measured tissue response with an arterial input, gives a direct estimate of myocardial blood flow. In this paper, we analyze the effects of delays in the contrast enhancement, that occur in collateral-dependent myocardium, where the tracer reaches the tissue region only through branches from other coronary arteries that form natural bypass vessels. We investigate how the delayed arrival of tracer alters the myocardial impulse response. Model-independent deconvolution is applied to determine the lag between arterial input and tissue enhancement. Experimental data in a porcine model of collateral development indicate that the delayed arrival of an injected tracer, measured at rest, is a useful marker to identify collateral-dependent myocardium, and predict its flow capacitance.
KW - Collateral circulation
KW - Deconvolution
KW - Magnetic resonance imaging
KW - Myocardial blood flow
KW - Tikhonov regularization
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U2 - 10.1109/TMI.2004.827969
DO - 10.1109/TMI.2004.827969
M3 - Article
C2 - 15250640
AN - SCOPUS:3142774916
SN - 0278-0062
VL - 23
SP - 881
EP - 890
JO - IEEE transactions on medical imaging
JF - IEEE transactions on medical imaging
IS - 7
ER -