Time course of tetrahydrocannabinol-induced changes in regional cerebral blood flow measured with positron emission tomography

Roy J. Mathew, William H. Wilson, Timothy G. Turkington, Thomas C. Hawk, R. Edward Coleman, Timothy R DeGrado, James Provenzale

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

While several studies are available on the immediate effects of marijuana and its active ingredient tetrahydrocannabinol (THC) on regional cerebral blood flow (rCBF), we examined the effects of intravenous infusion of THC on rCBF and behavior over a 120-min. period using positron emission tomography. Indices of rCBF, intoxication and physiology were measured at baseline and 30, 60, 90 and 120 min. after a 20-min. intravenous infusion of 0.15 or 0.25 mg/min. of THC, or placebo given to 47 subjects. The rCBF remained increased up to 120 min. after the high-dose THC infusion. Significant increases were seen in global perfusion and in the frontal, insular and anterior cingulate regions. Changes were greater in the right hemisphere. After the high dose, cerebellar flow was increased at both 30 and 60 min. The anterioposterior ratio of cortical rCBF increased in both hemispheres, and remained significantly greater than in the placebo condition until 120 min. in the right hemisphere. Intoxication peaked at 30 min. and remained elevated at 120 min. THC had significant effects on global CBF and rCBF, and feeling intoxicated accounted for changes in rCBF better than plasma level of THC.

Original languageEnglish (US)
Pages (from-to)173-185
Number of pages13
JournalPsychiatry Research - Neuroimaging
Volume116
Issue number3
DOIs
StatePublished - Dec 30 2002
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Dronabinol
Regional Blood Flow
Positron-Emission Tomography
Gyrus Cinguli
Intravenous Infusions
Placebos
Cannabis
Emotions
Perfusion

Keywords

  • Cerebral blood flow
  • Marijuana intoxication
  • Physiological changes
  • Positron emission tomography
  • Tetrahydrocannabinol
  • Time course

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Biological Psychiatry
  • Psychology(all)

Cite this

Time course of tetrahydrocannabinol-induced changes in regional cerebral blood flow measured with positron emission tomography. / Mathew, Roy J.; Wilson, William H.; Turkington, Timothy G.; Hawk, Thomas C.; Coleman, R. Edward; DeGrado, Timothy R; Provenzale, James.

In: Psychiatry Research - Neuroimaging, Vol. 116, No. 3, 30.12.2002, p. 173-185.

Research output: Contribution to journalArticle

Mathew, Roy J. ; Wilson, William H. ; Turkington, Timothy G. ; Hawk, Thomas C. ; Coleman, R. Edward ; DeGrado, Timothy R ; Provenzale, James. / Time course of tetrahydrocannabinol-induced changes in regional cerebral blood flow measured with positron emission tomography. In: Psychiatry Research - Neuroimaging. 2002 ; Vol. 116, No. 3. pp. 173-185.
@article{3dd590c0ad38499888416fad72aa39e8,
title = "Time course of tetrahydrocannabinol-induced changes in regional cerebral blood flow measured with positron emission tomography",
abstract = "While several studies are available on the immediate effects of marijuana and its active ingredient tetrahydrocannabinol (THC) on regional cerebral blood flow (rCBF), we examined the effects of intravenous infusion of THC on rCBF and behavior over a 120-min. period using positron emission tomography. Indices of rCBF, intoxication and physiology were measured at baseline and 30, 60, 90 and 120 min. after a 20-min. intravenous infusion of 0.15 or 0.25 mg/min. of THC, or placebo given to 47 subjects. The rCBF remained increased up to 120 min. after the high-dose THC infusion. Significant increases were seen in global perfusion and in the frontal, insular and anterior cingulate regions. Changes were greater in the right hemisphere. After the high dose, cerebellar flow was increased at both 30 and 60 min. The anterioposterior ratio of cortical rCBF increased in both hemispheres, and remained significantly greater than in the placebo condition until 120 min. in the right hemisphere. Intoxication peaked at 30 min. and remained elevated at 120 min. THC had significant effects on global CBF and rCBF, and feeling intoxicated accounted for changes in rCBF better than plasma level of THC.",
keywords = "Cerebral blood flow, Marijuana intoxication, Physiological changes, Positron emission tomography, Tetrahydrocannabinol, Time course",
author = "Mathew, {Roy J.} and Wilson, {William H.} and Turkington, {Timothy G.} and Hawk, {Thomas C.} and Coleman, {R. Edward} and DeGrado, {Timothy R} and James Provenzale",
year = "2002",
month = "12",
day = "30",
doi = "10.1016/S0925-4927(02)00069-0",
language = "English (US)",
volume = "116",
pages = "173--185",
journal = "Psychiatry Research - Neuroimaging",
issn = "0925-4927",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Time course of tetrahydrocannabinol-induced changes in regional cerebral blood flow measured with positron emission tomography

AU - Mathew, Roy J.

AU - Wilson, William H.

AU - Turkington, Timothy G.

AU - Hawk, Thomas C.

AU - Coleman, R. Edward

AU - DeGrado, Timothy R

AU - Provenzale, James

PY - 2002/12/30

Y1 - 2002/12/30

N2 - While several studies are available on the immediate effects of marijuana and its active ingredient tetrahydrocannabinol (THC) on regional cerebral blood flow (rCBF), we examined the effects of intravenous infusion of THC on rCBF and behavior over a 120-min. period using positron emission tomography. Indices of rCBF, intoxication and physiology were measured at baseline and 30, 60, 90 and 120 min. after a 20-min. intravenous infusion of 0.15 or 0.25 mg/min. of THC, or placebo given to 47 subjects. The rCBF remained increased up to 120 min. after the high-dose THC infusion. Significant increases were seen in global perfusion and in the frontal, insular and anterior cingulate regions. Changes were greater in the right hemisphere. After the high dose, cerebellar flow was increased at both 30 and 60 min. The anterioposterior ratio of cortical rCBF increased in both hemispheres, and remained significantly greater than in the placebo condition until 120 min. in the right hemisphere. Intoxication peaked at 30 min. and remained elevated at 120 min. THC had significant effects on global CBF and rCBF, and feeling intoxicated accounted for changes in rCBF better than plasma level of THC.

AB - While several studies are available on the immediate effects of marijuana and its active ingredient tetrahydrocannabinol (THC) on regional cerebral blood flow (rCBF), we examined the effects of intravenous infusion of THC on rCBF and behavior over a 120-min. period using positron emission tomography. Indices of rCBF, intoxication and physiology were measured at baseline and 30, 60, 90 and 120 min. after a 20-min. intravenous infusion of 0.15 or 0.25 mg/min. of THC, or placebo given to 47 subjects. The rCBF remained increased up to 120 min. after the high-dose THC infusion. Significant increases were seen in global perfusion and in the frontal, insular and anterior cingulate regions. Changes were greater in the right hemisphere. After the high dose, cerebellar flow was increased at both 30 and 60 min. The anterioposterior ratio of cortical rCBF increased in both hemispheres, and remained significantly greater than in the placebo condition until 120 min. in the right hemisphere. Intoxication peaked at 30 min. and remained elevated at 120 min. THC had significant effects on global CBF and rCBF, and feeling intoxicated accounted for changes in rCBF better than plasma level of THC.

KW - Cerebral blood flow

KW - Marijuana intoxication

KW - Physiological changes

KW - Positron emission tomography

KW - Tetrahydrocannabinol

KW - Time course

UR - http://www.scopus.com/inward/record.url?scp=0037203090&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037203090&partnerID=8YFLogxK

U2 - 10.1016/S0925-4927(02)00069-0

DO - 10.1016/S0925-4927(02)00069-0

M3 - Article

C2 - 12477601

AN - SCOPUS:0037203090

VL - 116

SP - 173

EP - 185

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

SN - 0925-4927

IS - 3

ER -