Time course of lysophosphatidylcholine release from ischemic human myocardium parallels the time course of early ischemic ventricular arrhythmia

Steven R. Sedlis, Mae Hom, Jeffrey M. Sequeira, Marc Tritel, Aaron Gindea, Jack H. Ladenson, Allan S. Jaffe, Rick Esposito

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Background: We determined the kinetics of the release of lysophosphatidylcholine (LPC) into the coronary sinus of patients undergoing stress tests after coronary artery bypass grafting. The kinetics were consistent with a role for this amphiphile in the pathogenesis of ischemic ventricular arrhythmia, a major cause of sudden death. Methods: Stress testing was initiated in the operating suite by pacing at a rate of 160 beats/min for 2 min. Ischemia was then induced by clamping the bypass grafts to the anterior wall for a maximal time of 4 min. Results: The pacing procedure induced a prompt but reversible increase in coronary sinus LPC concentration from a baseline of 60.9 ± 2.5 to 83.8 ± 5.0 μmol/l via pacing alone, and a further increase to 101.8 ± 6.7 μmol/I when the grafts were clamped for 2 min (P< 0.01). Six minutes after the cessation of pacing, LPC concentration returned to 67.5 ± 4.4 μmol/I. Conclusions: These results demonstrate that severe myocardial ischemia is an agonist for rapid release of LPC from the myocardium. Kinetics of this release paralleled the time- course of early onset of electrophysiologic changes in isolated myocytes and perfused heart preparations in vitro. These results indicate that LPC may have an important role in the pathogenesis of ischemic ventricular arrhythmia in patients.

Original languageEnglish (US)
Pages (from-to)19-27
Number of pages9
JournalCoronary Artery Disease
Volume8
Issue number1
StatePublished - Apr 24 1997

Keywords

  • coronary artery bypass grafting
  • lysophostidylcholine
  • myocardial ischemia
  • stress testing
  • ventricular arrythmia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Sedlis, S. R., Hom, M., Sequeira, J. M., Tritel, M., Gindea, A., Ladenson, J. H., Jaffe, A. S., & Esposito, R. (1997). Time course of lysophosphatidylcholine release from ischemic human myocardium parallels the time course of early ischemic ventricular arrhythmia. Coronary Artery Disease, 8(1), 19-27.