TIEG proteins join the Smads as TGF-β-regulated transcription factors that control pancreatic cell growth

Tiffany Cook, Raul Urrutia

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

The control of epithelial cell proliferation, differentiation, and apoptosis requires a balance between signaling and transcriptional regulation. Recent developments in pancreatic cell research have revealed that transforming growth factor-β (TGF-β) signaling is important for the regulation of each of these phenomena. More importantly, perturbations in this pathway are associated with pancreatic cancer. A chief example of these alterations is the mutation in the TGF-β-regulated transcription factor Smad4/DPC4 that is found in a large percentage of pancreatic tumors. Surprisingly, studies on transcription factors have remained an underrepresented area of pancreatic research. However, the discovery of Smad4/DPC4 as a transcription factor fueled further studies aimed at characterizing transcription factors involved in normal and neoplastic pancreatic cell growth. Our laboratory recently described the existence of a novel family of zinc finger transcription factors, TGF-β-inducible early- response gene (TIEG)1 and TIEG2, from the exocrine pancreas that, similarly to Smads, participate in the TGF-β response and inhibit epithelial cell proliferation. This review therefore focuses on describing the structure and function of these two families of transcription factor proteins that are becoming key players in the regulation of pancreatic cell growth.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume278
Issue number4 41-4
StatePublished - Apr 2000

Fingerprint

Transforming Growth Factors
Transcription Factors
Growth
Proteins
Epithelial Cells
Cell Proliferation
Exocrine Pancreas
Zinc Fingers
Pancreatic Neoplasms
Research
Cell Differentiation
Apoptosis
Mutation
Genes
Neoplasms

Keywords

  • Apoptosis
  • Differentiation
  • Early-response genes
  • Proliferation
  • Zinc finger transcription factor

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology
  • Physiology (medical)

Cite this

TIEG proteins join the Smads as TGF-β-regulated transcription factors that control pancreatic cell growth. / Cook, Tiffany; Urrutia, Raul.

In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 278, No. 4 41-4, 04.2000.

Research output: Contribution to journalArticle

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