TIA-1 expression in lymphoid neoplasms: Identification of subsets with cytotoxic T lymphocyte or natural killer cell differentiation

Raymond E. Felgar, William R. Macon, Marsha C. Kinney, Shelley Roberts, Theresa Pasha, Kevin E. Salhany

Research output: Contribution to journalArticle

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Abstract

TIA-1 is a 15-kd cytotoxic granule-associated protein expressed in natural killer (NK) cells and cytotoxic T lymphocytes. TIA-1 expression was evaluated by paraffin immunohistochemistry in 115 T-or NK-cell neoplasms, 45 B-cell neoplasms, and 45 Hodgkin's lymphomas. TIA-1-positive granules were identified within the cytoplasm of neoplastic cells in 6/6 large granular lymphocytic leukemias, 11/11 hepatosplenic T-cell lymphomas, 15/15 intestinal T-cell lymphomas, 6/6 NK-like T-cell lymphomas of no special type, 2/2 NK- cell lymphomas, 8/9 nasal T/NK-cell lymphomas, 7/8 subcutaneous T-cell lymphomas, 4/5 pulmonary, T- or NK-cell angiocentric lymphomas (lymphomatoid granulomatosis), 12/19 T-cell anaplastic large-cell lymphomas. 2/12 nodal peripheral T-cell lymphomas, 1/3 CD8+ cutaneous T=cell lymphomas, and 5/38 classical Hodgkin's disease. All B-cell neoplasms, nodular lymphocyte- predominant Hodgkin's disease (7 cases), CD4+ cutaneous T-cell lymphomas (6 cases), adult T-cell leukemia/lymphomas (3 cases), T-cell chronic or prolymphocytic leukemias (3 cases), and T-cell lymphoblastic leukemia/lymphomas (7 cases) were TIA-1 negative. These findings indicate that most large granular lymphocytic leukemias, hepatosplenic T-cell lymphomas, intestinal T-cell lymphomas, NK-like T-cell lymphomas, NK-cell lymphomas, nasal T/NK-cell lymphomas, subcutaneous T-cell lymphomas, pulmonary angiocentric lymphomas of T or NK phenotype, and anaplastic large- cell lymphomas are cytotoxic T or NK-cell neoplasms.

Original languageEnglish (US)
Pages (from-to)1893-1900
Number of pages8
JournalAmerican Journal of Pathology
Volume150
Issue number6
StatePublished - 1997
Externally publishedYes

Fingerprint

T-Cell Lymphoma
Cytotoxic T-Lymphocytes
Natural Killer Cells
Natural Killer T-Cells
Cell Differentiation
Lymphoma
Neoplasms
Large Granular Lymphocytic Leukemia
Hodgkin Disease
Anaplastic Large-Cell Lymphoma
Cutaneous T-Cell Lymphoma
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Nose
B-Lymphocytes
Lymphomatoid Granulomatosis
T-Cell Prolymphocytic Leukemia
Peripheral T-Cell Lymphoma
T-Cell Leukemia
Adult T Cell Leukemia Lymphoma
Lung

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Felgar, R. E., Macon, W. R., Kinney, M. C., Roberts, S., Pasha, T., & Salhany, K. E. (1997). TIA-1 expression in lymphoid neoplasms: Identification of subsets with cytotoxic T lymphocyte or natural killer cell differentiation. American Journal of Pathology, 150(6), 1893-1900.

TIA-1 expression in lymphoid neoplasms : Identification of subsets with cytotoxic T lymphocyte or natural killer cell differentiation. / Felgar, Raymond E.; Macon, William R.; Kinney, Marsha C.; Roberts, Shelley; Pasha, Theresa; Salhany, Kevin E.

In: American Journal of Pathology, Vol. 150, No. 6, 1997, p. 1893-1900.

Research output: Contribution to journalArticle

Felgar, RE, Macon, WR, Kinney, MC, Roberts, S, Pasha, T & Salhany, KE 1997, 'TIA-1 expression in lymphoid neoplasms: Identification of subsets with cytotoxic T lymphocyte or natural killer cell differentiation', American Journal of Pathology, vol. 150, no. 6, pp. 1893-1900.
Felgar, Raymond E. ; Macon, William R. ; Kinney, Marsha C. ; Roberts, Shelley ; Pasha, Theresa ; Salhany, Kevin E. / TIA-1 expression in lymphoid neoplasms : Identification of subsets with cytotoxic T lymphocyte or natural killer cell differentiation. In: American Journal of Pathology. 1997 ; Vol. 150, No. 6. pp. 1893-1900.
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