TY - JOUR
T1 - Thyrotropin secretion by thyrotropinomas is characterized by increased pulse frequency, delayed diurnal rhythm, enhanced basal secretion, spikiness, and disorderliness
AU - Roelfsema, Ferdinand
AU - Pereira, Alberto M.
AU - Keenan, Daniel M.
AU - Veldhuis, Johannes D.
AU - Romijn, Johannes A.
PY - 2008/10
Y1 - 2008/10
N2 - Context: Hormone secretion by somatotropinomas, corticotropinomas, and prolactinomas exhibits increased pulsatility and basal secretion, accompanied by greater disorderliness. Objective: Our objective was to evaluate TSH secretion by thyrotropinomas with up-to-date analytical and mathematical tools. Design: Twenty-four hour blood samplings at 10-min intervals in a clinical research laboratory in five patients with a thyrotropinoma and 10 healthy age- and gender-matched controls were performed. The obtained serum TSH profiles were analyzed with a new deconvolution method, approximate entropy, Cosinor analysis, and by quantification of spikiness. Results: TSH burst frequency and basal secretion were increased in patients compared with controls. TSH secretion patterns in patients were more irregular than in controls, but the diurnal rhythm was preserved at a higher mean in all patients, although with a 2-h phase delay. Conclusion: TSH secretion by thyrotropinomas shares many characteristics with other pituitary hormone-secreting adenomas.
AB - Context: Hormone secretion by somatotropinomas, corticotropinomas, and prolactinomas exhibits increased pulsatility and basal secretion, accompanied by greater disorderliness. Objective: Our objective was to evaluate TSH secretion by thyrotropinomas with up-to-date analytical and mathematical tools. Design: Twenty-four hour blood samplings at 10-min intervals in a clinical research laboratory in five patients with a thyrotropinoma and 10 healthy age- and gender-matched controls were performed. The obtained serum TSH profiles were analyzed with a new deconvolution method, approximate entropy, Cosinor analysis, and by quantification of spikiness. Results: TSH burst frequency and basal secretion were increased in patients compared with controls. TSH secretion patterns in patients were more irregular than in controls, but the diurnal rhythm was preserved at a higher mean in all patients, although with a 2-h phase delay. Conclusion: TSH secretion by thyrotropinomas shares many characteristics with other pituitary hormone-secreting adenomas.
UR - http://www.scopus.com/inward/record.url?scp=53749088321&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=53749088321&partnerID=8YFLogxK
U2 - 10.1210/jc.2008-1145
DO - 10.1210/jc.2008-1145
M3 - Article
C2 - 18682501
AN - SCOPUS:53749088321
SN - 0021-972X
VL - 93
SP - 4052
EP - 4057
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 10
ER -