Shear wave elastography is a quantitative elasticity‐based imaging method that has been of great research interest for thyroid nodule differentiation. This chapter focuses on application of shear wave elastography techniques, more specifically comb‐push ultrasound shear elastography (CUSE), in thyroid imaging. It presents the in vivo results of shearwave elastography on thyroid. The chapter discusses the future developments and potential impact of CUSE in thyroid imaging. Real‐time ultrasound has revolutionized the clinical practice of thyroidology. Ultrasonography can identify thyroid nodules with high accuracy in determining the number and size of nodules. Elasticity imaging is an emerging imaging modality that can noninvasively provide tissue viscoelasticity information. Shear wave elastography techniques use radiation force of ultrasound to induce shear waves within the tissue, and by measuring the generated shear wave speed one can make a quantitative estimation of tissue stiffness.
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