Thymic hyperplasia presenting as anterior mediastinal mass in 2 patients with graves disease

Adriane I. Budavari, Michael D. Whitaker, Richard A. Helmers

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Graves disease is an autoimmune thyroid condition characterized by the production of autoantibodies against the thyrotropin receptor. The autoantibodies mimic the effect of the hormone on thyroid cells, which stimulates autonomous production of thyroxine and triiodothyronine. It has been hypothesized that cross-reactivity of autoantibodies may result in Graves ophthalmopathy and dermopathy. A seldom-recognized feature of Graves disease is thymic hyperplasia. We report 2 patients with Graves disease and incidentally discovered anterior mediastinal masses presumed to be thymic hyperplasia. In both cases, these masses regressed spontaneously after treatment of hyperthyroidism.

Original languageEnglish (US)
Article number62220
Pages (from-to)495-499
Number of pages5
JournalMayo Clinic proceedings
Volume77
Issue number5
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Medicine(all)

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