Thrombotic Microangiopathy Care Pathway: A Consensus Statement for the Mayo Clinic Complement Alternative Pathway-Thrombotic Microangiopathy (CAP-TMA) Disease-Oriented Group

Ronald S. Go, Jeffrey L. Winters, Nelson Leung, David L. Murray, Maria A. Willrich, Roshini S. Abraham, Hatem Amer, William Hogan, Ariela L. Marshall, Sanjeev Sethi, Cheryl L. Tran, Dong Chen, Rajiv K. Pruthi, Aneel Arjun Ashrani, Fernando Custodio Fervenza, Carl H. Cramer, Vilmarie Rodriguez, Alexandra P. Wolanskyj, Stephan Thome, C. Christopher HookRonald S. Go, Jeffrey L. Winters, Nelson Leung, David L. Murray, Maria A. Willrich, Roshini S. Abraham, Hatem Amer, William J. Hogan, Ariela L. Marshall, Sanjeev M Sethi, Cheryl L. Tran, Dong Chen, Rajiv K. Pruthi, Aneel A. Ashrani, Fernando C. Fervenza, Carl H. Cramer, C. Christopher Hook, Vesna D Garovic, Jennifer C. Yui, Juliana Perez Botero

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Abstract

Thrombotic microangiopathies (TMAs) comprise a heterogeneous set of conditions linked by a common histopathologic finding of endothelial damage resulting in microvascular thromboses and potentially serious complications. The typical clinical presentation is microangiopathic hemolytic anemia accompanied by thrombocytopenia with varying degrees of organ ischemia. The differential diagnoses are generally broad, while the workup is frequently complex and can be confusing. This statement represents the joint recommendations from a multidisciplinary team of Mayo Clinic physicians specializing in the management of TMA. It comprises a series of evidence- and consensus-based clinical pathways developed to allow a uniform approach to the spectrum of care including when to suspect TMA, what differential diagnoses to consider, which diagnostic tests to order, and how to provide initial empiric therapy, as well as some guidance on subsequent management.

Original languageEnglish (US)
Pages (from-to)1189-1211
Number of pages23
JournalMayo Clinic Proceedings
Volume91
Issue number9
DOIs
StatePublished - Sep 1 2016

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Go, R. S., Winters, J. L., Leung, N., Murray, D. L., Willrich, M. A., Abraham, R. S., Amer, H., Hogan, W., Marshall, A. L., Sethi, S., Tran, C. L., Chen, D., Pruthi, R. K., Ashrani, A. A., Fervenza, F. C., Cramer, C. H., Rodriguez, V., Wolanskyj, A. P., Thome, S., ... Botero, J. P. (2016). Thrombotic Microangiopathy Care Pathway: A Consensus Statement for the Mayo Clinic Complement Alternative Pathway-Thrombotic Microangiopathy (CAP-TMA) Disease-Oriented Group. Mayo Clinic Proceedings, 91(9), 1189-1211. https://doi.org/10.1016/j.mayocp.2016.05.015