TY - JOUR
T1 - Thrombosis in myelofibrosis
T2 - Prior thrombosis is the only predictive factor and most venous events are provoked
AU - Elliott, Michelle Ann
AU - Pardanani, Animesh
AU - Lasho, Terra L.
AU - Schwager, Susan M.
AU - Tefferi, Ayalew
PY - 2010/10
Y1 - 2010/10
N2 - In a retrospective analysis of 205 patients (median age 62 years) with primary myelofibrosis and known JAK2V617F mutational status, 13.2% experienced a vaso-occlusive event at or prior to their diagnosis. After a median follow up of 31 months, post-diagnosis thrombosis occurred in 22 patients (10.7%), including 9 (4.4%) and 16 (7.8%) patients with a total of 9 arterial and 24 venous events, respectively. The majority (71%) of the venous events were temporally associated with other exogenous risk factors for thrombosis such as surgery, line placement or hormonal therapy. On multivariable analysis that included age, JAK2V617F mutation status and leukocyte count as covariates, history of thrombosis was the only predictive variable in general (P=0.04) or when arterial (P=0.007) and venous (P=0.02) thromboses were analyzed separately. The current study demonstrates a higher prevalence of venous, as opposed to arterial, events in PMF, postdiagnosis, and clarifies their nature as being mostly provoked.
AB - In a retrospective analysis of 205 patients (median age 62 years) with primary myelofibrosis and known JAK2V617F mutational status, 13.2% experienced a vaso-occlusive event at or prior to their diagnosis. After a median follow up of 31 months, post-diagnosis thrombosis occurred in 22 patients (10.7%), including 9 (4.4%) and 16 (7.8%) patients with a total of 9 arterial and 24 venous events, respectively. The majority (71%) of the venous events were temporally associated with other exogenous risk factors for thrombosis such as surgery, line placement or hormonal therapy. On multivariable analysis that included age, JAK2V617F mutation status and leukocyte count as covariates, history of thrombosis was the only predictive variable in general (P=0.04) or when arterial (P=0.007) and venous (P=0.02) thromboses were analyzed separately. The current study demonstrates a higher prevalence of venous, as opposed to arterial, events in PMF, postdiagnosis, and clarifies their nature as being mostly provoked.
KW - JAKV617F
KW - Primary myelofibrosis
KW - Thrombosis
UR - http://www.scopus.com/inward/record.url?scp=77957779176&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957779176&partnerID=8YFLogxK
U2 - 10.3324/haematol.2010.025064
DO - 10.3324/haematol.2010.025064
M3 - Article
C2 - 20884719
AN - SCOPUS:77957779176
SN - 0390-6078
VL - 95
SP - 1788
EP - 1791
JO - Haematologica
JF - Haematologica
IS - 10
ER -