Thrombolysis in patients with transient neurologic deficits

Patrick Lyden, M. Lu, T. Kwiatkowski, M. Frankel, S. Levine, J. Broderick, Thomas G Brott

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

What is the risk of thrombolysis in patients with acute stroke who might recover without treatment? In the National Institute of Neurological Disorders and Stroke rt-PA for Acute Stroke Trial, 2.6% of patients taking placebo showed spontaneous 24-hour recovery, compared to 11.5% of recombinant tissue-type plasminogen activator (rt-PA)-treated patients (p < 0.001). There were no symptomatic ICH in the patients taking placebo; one hypertensive, rt-PA-treated patient hemorrhaged. Assuming the National Institute of Neurological Disorders and Stroke protocol is followed rigorously, patients with acute stroke rarely recover spontaneously and the thrombolytic risk is low.

Original languageEnglish (US)
Pages (from-to)2125-2128
Number of pages4
JournalNeurology
Volume57
Issue number11
StatePublished - Dec 11 2001

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Neurologic Manifestations
Tissue Plasminogen Activator
National Institute of Neurological Disorders and Stroke
Stroke
Placebos

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lyden, P., Lu, M., Kwiatkowski, T., Frankel, M., Levine, S., Broderick, J., & Brott, T. G. (2001). Thrombolysis in patients with transient neurologic deficits. Neurology, 57(11), 2125-2128.

Thrombolysis in patients with transient neurologic deficits. / Lyden, Patrick; Lu, M.; Kwiatkowski, T.; Frankel, M.; Levine, S.; Broderick, J.; Brott, Thomas G.

In: Neurology, Vol. 57, No. 11, 11.12.2001, p. 2125-2128.

Research output: Contribution to journalArticle

Lyden, P, Lu, M, Kwiatkowski, T, Frankel, M, Levine, S, Broderick, J & Brott, TG 2001, 'Thrombolysis in patients with transient neurologic deficits', Neurology, vol. 57, no. 11, pp. 2125-2128.
Lyden P, Lu M, Kwiatkowski T, Frankel M, Levine S, Broderick J et al. Thrombolysis in patients with transient neurologic deficits. Neurology. 2001 Dec 11;57(11):2125-2128.
Lyden, Patrick ; Lu, M. ; Kwiatkowski, T. ; Frankel, M. ; Levine, S. ; Broderick, J. ; Brott, Thomas G. / Thrombolysis in patients with transient neurologic deficits. In: Neurology. 2001 ; Vol. 57, No. 11. pp. 2125-2128.
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