Thrombolysis in patients with transient neurologic deficits

Patrick Lyden, M. Lu, T. Kwiatkowski, M. Frankel, S. Levine, J. Broderick, T. Brott

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

What is the risk of thrombolysis in patients with acute stroke who might recover without treatment? In the National Institute of Neurological Disorders and Stroke rt-PA for Acute Stroke Trial, 2.6% of patients taking placebo showed spontaneous 24-hour recovery, compared to 11.5% of recombinant tissue-type plasminogen activator (rt-PA)-treated patients (p < 0.001). There were no symptomatic ICH in the patients taking placebo; one hypertensive, rt-PA-treated patient hemorrhaged. Assuming the National Institute of Neurological Disorders and Stroke protocol is followed rigorously, patients with acute stroke rarely recover spontaneously and the thrombolytic risk is low.

Original languageEnglish (US)
Pages (from-to)2125-2128
Number of pages4
JournalNeurology
Volume57
Issue number11
DOIs
StatePublished - Dec 11 2001

ASJC Scopus subject areas

  • Clinical Neurology

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    Lyden, P., Lu, M., Kwiatkowski, T., Frankel, M., Levine, S., Broderick, J., & Brott, T. (2001). Thrombolysis in patients with transient neurologic deficits. Neurology, 57(11), 2125-2128. https://doi.org/10.1212/WNL.57.11.2125