Thrombolysis for cerebral ischemia

Jennifer E. Fugate, Elias A. Giraldo, Alejandro Rabinstein

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The care for patients with acute ischemic stroke has been revolutionized by the clinical application of fibrinolysis. Intravenous recombinant tissue plasminogen activator (rt-PA) has been proven to improve functional outcomes following acute ischemic stroke and can be administered to a select group of patients up to 4.5 h after symptom onset. Time from symptom onset to thrombolysis is the most important determinant of the success of treatment, with greatest efficacy if given within 90 min. Hospitals should implement standardized processes and protocols for acute stroke to guide immediate patient assessment, brain imaging, drug administration, and post-thrombolysis care. In this article we review the clinical application of thrombolysis, care of acute stroke patients, current evidence regarding fibrinolysis, and future direction of penumbral imaging to select candidates for reperfusion therapies.

Original languageEnglish (US)
Article numberArticle 139
JournalFrontiers in Neurology
VolumeOCT
DOIs
StatePublished - Dec 1 2010

Fingerprint

Brain Ischemia
Stroke
Fibrinolysis
Tissue Plasminogen Activator
Neuroimaging
Reperfusion
Patient Care
Therapeutics
Pharmaceutical Preparations

Keywords

  • Acute stroke
  • Cerebrovascular
  • t-PA
  • Thrombolysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Thrombolysis for cerebral ischemia. / Fugate, Jennifer E.; Giraldo, Elias A.; Rabinstein, Alejandro.

In: Frontiers in Neurology, Vol. OCT, Article 139, 01.12.2010.

Research output: Contribution to journalArticle

Fugate, Jennifer E. ; Giraldo, Elias A. ; Rabinstein, Alejandro. / Thrombolysis for cerebral ischemia. In: Frontiers in Neurology. 2010 ; Vol. OCT.
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