Thrombocytosis distinguishes POEMS syndrome from chronic inflammatory demyelinating polyneuropathy

Elie Naddaf; Angela Dispenzieri; Jay Mandrekar; Michelle L. Mauermann

doi:10.1002/mus.24768

Thrombocytosis distinguishes POEMS syndrome from chronic inflammatory demyelinating polyneuropathy

Elie Naddaf, Angela Dispenzieri, Jay Mandrekar, Michelle L. Mauermann

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Introduction: POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes) syndrome may be mistaken for chronic inflammatory demyelinating polyneuropathy (CIDP). Differentiating the 2 entities is crucial, as there are major treatment implications. Methods: We compared platelet counts in 136 POEMS patients and 67 CIDP controls. Results: Of the patients with POEMS, 53.7% had thrombocytosis, compared with 1.5% of those with CIDP (P < 0.0001). The median platelet count in patients with POEMS was 467,000/μl compared with 275,000/μl in those with CIDP (P < 0.0001). Conclusions: Thrombocytosis is a helpful indicator to prompt clinicians to consider the diagnosis of POEMS syndrome in patients who are thought to have CIDP, and is an important reminder of the increased risk of thrombotic events in POEMS syndrome.

Original language	English (US)
Pages (from-to)	658-659
Number of pages	2
Journal	Muscle and Nerve
Volume	52
Issue number	4
DOIs	https://doi.org/10.1002/mus.24768
State	Published - Oct 1 2015

Keywords

CIDP
Monoclonal gammopathy
POEMS syndrome
Polyradiculoneuropathy
Thrombocytosis

ASJC Scopus subject areas

Physiology
Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)

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title = "Thrombocytosis distinguishes POEMS syndrome from chronic inflammatory demyelinating polyneuropathy",

abstract = "Introduction: POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes) syndrome may be mistaken for chronic inflammatory demyelinating polyneuropathy (CIDP). Differentiating the 2 entities is crucial, as there are major treatment implications. Methods: We compared platelet counts in 136 POEMS patients and 67 CIDP controls. Results: Of the patients with POEMS, 53.7% had thrombocytosis, compared with 1.5% of those with CIDP (P < 0.0001). The median platelet count in patients with POEMS was 467,000/μl compared with 275,000/μl in those with CIDP (P < 0.0001). Conclusions: Thrombocytosis is a helpful indicator to prompt clinicians to consider the diagnosis of POEMS syndrome in patients who are thought to have CIDP, and is an important reminder of the increased risk of thrombotic events in POEMS syndrome.",

keywords = "CIDP, Monoclonal gammopathy, POEMS syndrome, Polyradiculoneuropathy, Thrombocytosis",

author = "Elie Naddaf and Angela Dispenzieri and Jay Mandrekar and Mauermann, {Michelle L.}",

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doi = "10.1002/mus.24768",

language = "English (US)",

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AU - Naddaf, Elie

AU - Dispenzieri, Angela

AU - Mandrekar, Jay

AU - Mauermann, Michelle L.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Introduction: POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes) syndrome may be mistaken for chronic inflammatory demyelinating polyneuropathy (CIDP). Differentiating the 2 entities is crucial, as there are major treatment implications. Methods: We compared platelet counts in 136 POEMS patients and 67 CIDP controls. Results: Of the patients with POEMS, 53.7% had thrombocytosis, compared with 1.5% of those with CIDP (P < 0.0001). The median platelet count in patients with POEMS was 467,000/μl compared with 275,000/μl in those with CIDP (P < 0.0001). Conclusions: Thrombocytosis is a helpful indicator to prompt clinicians to consider the diagnosis of POEMS syndrome in patients who are thought to have CIDP, and is an important reminder of the increased risk of thrombotic events in POEMS syndrome.

AB - Introduction: POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes) syndrome may be mistaken for chronic inflammatory demyelinating polyneuropathy (CIDP). Differentiating the 2 entities is crucial, as there are major treatment implications. Methods: We compared platelet counts in 136 POEMS patients and 67 CIDP controls. Results: Of the patients with POEMS, 53.7% had thrombocytosis, compared with 1.5% of those with CIDP (P < 0.0001). The median platelet count in patients with POEMS was 467,000/μl compared with 275,000/μl in those with CIDP (P < 0.0001). Conclusions: Thrombocytosis is a helpful indicator to prompt clinicians to consider the diagnosis of POEMS syndrome in patients who are thought to have CIDP, and is an important reminder of the increased risk of thrombotic events in POEMS syndrome.

KW - CIDP

KW - Monoclonal gammopathy

KW - POEMS syndrome

KW - Polyradiculoneuropathy

KW - Thrombocytosis

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Thrombocytosis distinguishes POEMS syndrome from chronic inflammatory demyelinating polyneuropathy

Abstract

Keywords

ASJC Scopus subject areas

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