Abstract
Introduction: A variable repertoire of coagulation protein expression is observed in different cancers. We evaluated expression of thrombin in prostate tissue. Methods: Detection of thrombin was performed using quantitative real-time PCR in fresh tissue and in situ hybridization (ISH) in archival prostate tissue and by immunohistochemistry of prostate tissue microarrays. Results: (Pro)thrombin mRNA expression was detected in cancer tissue and localized to prostatic epithelium and stroma by ISH. Thrombin protein was detected in stroma of benign and malignant epithelium (p <.05). Conclusions: Prostate tissue is a rich reservoir of thrombin. This may have potential for developing antithrombin-based cancer therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 62-67 |
| Number of pages | 6 |
| Journal | Cancer Investigation |
| Volume | 29 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2011 |
Keywords
- Coagulation
- Prostatic neoplasms
- Prothrombin
ASJC Scopus subject areas
- Oncology
- Cancer Research