Thrombin expression in prostate: A novel finding

Manish Kohli, Karin Williams, Jorge L. Yao, Richard A. Dennis, Jiaoti Huang, Jay Reeder, William A. Ricke

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Introduction: A variable repertoire of coagulation protein expression is observed in different cancers. We evaluated expression of thrombin in prostate tissue. Methods: Detection of thrombin was performed using quantitative real-time PCR in fresh tissue and in situ hybridization (ISH) in archival prostate tissue and by immunohistochemistry of prostate tissue microarrays. Results: (Pro)thrombin mRNA expression was detected in cancer tissue and localized to prostatic epithelium and stroma by ISH. Thrombin protein was detected in stroma of benign and malignant epithelium (p <.05). Conclusions: Prostate tissue is a rich reservoir of thrombin. This may have potential for developing antithrombin-based cancer therapy.

Original languageEnglish (US)
Pages (from-to)62-67
Number of pages6
JournalCancer Investigation
Volume29
Issue number1
DOIs
StatePublished - Jan 2011

Keywords

  • Coagulation
  • Prostatic neoplasms
  • Prothrombin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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