Three-dimensional x-ray imaging of the anatomy and function of the lungs and pulmonary arteries in dogs following single lung transplant

Qing Hua M D Wu, Christopher G M D McGregor, Xue Si M D Wu, Mauro M D Rinaldi, Folke N M D Nilsson, Henry D M D Tazelaar, Erik L M D Ritman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

It was the goal of this study to see if relatively noninvasive CT studies could provide a quantitative index of acute lung rejection in single lung transplantation. Using volume scanning fast CT, the change in cross-sectional area of the major pulmonary arteries from systole to diastole, regional lung perfusion and ventilation was measured in 12 dogs with left lung allotransplantation before and during rejection and four dogs with left lung autotransplantation. All dogs were anesthetized and scanned in a fast computed tomography scanner (dynamic spatial reconstructor - DSR) during several ventilatory cycles and again during injection of contrast medium into the right atrium. There was significant reduction of regional air content, ventilation, perfusion and pulmonary artery compliance during rejection of the transplanted lung. The severity of these changes related linearly with the histological indices of rejection. It is concluded that minimally invasive dynamic CT imaging of transplanted lung can be used to detect acute rejection and its severity.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsEric A. Hoffman
Pages55-62
Number of pages8
Volume2709
StatePublished - 1996
Externally publishedYes
EventMedical Imaging 1996: Physiology and Function from Multidimensional Images - Newport Beach, CA, USA
Duration: Feb 11 1996Feb 13 1996

Other

OtherMedical Imaging 1996: Physiology and Function from Multidimensional Images
CityNewport Beach, CA, USA
Period2/11/962/13/96

Fingerprint

Transplants
dogs
anatomy
arteries
lungs
Ventilation
Contrast media
rejection
Imaging techniques
X rays
Tomography
x rays
Scanning
ventilation
Air
diastole
systole
transplantation
scanners
tomography

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Wu, Q. H. M. D., McGregor, C. G. M. D., Wu, X. S. M. D., Rinaldi, M. M. D., Nilsson, F. N. M. D., Tazelaar, H. D. M. D., & Ritman, E. L. M. D. (1996). Three-dimensional x-ray imaging of the anatomy and function of the lungs and pulmonary arteries in dogs following single lung transplant. In E. A. Hoffman (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2709, pp. 55-62)

Three-dimensional x-ray imaging of the anatomy and function of the lungs and pulmonary arteries in dogs following single lung transplant. / Wu, Qing Hua M D; McGregor, Christopher G M D; Wu, Xue Si M D; Rinaldi, Mauro M D; Nilsson, Folke N M D; Tazelaar, Henry D M D; Ritman, Erik L M D.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / Eric A. Hoffman. Vol. 2709 1996. p. 55-62.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Wu, QHMD, McGregor, CGMD, Wu, XSMD, Rinaldi, MMD, Nilsson, FNMD, Tazelaar, HDMD & Ritman, ELMD 1996, Three-dimensional x-ray imaging of the anatomy and function of the lungs and pulmonary arteries in dogs following single lung transplant. in EA Hoffman (ed.), Proceedings of SPIE - The International Society for Optical Engineering. vol. 2709, pp. 55-62, Medical Imaging 1996: Physiology and Function from Multidimensional Images, Newport Beach, CA, USA, 2/11/96.
Wu QHMD, McGregor CGMD, Wu XSMD, Rinaldi MMD, Nilsson FNMD, Tazelaar HDMD et al. Three-dimensional x-ray imaging of the anatomy and function of the lungs and pulmonary arteries in dogs following single lung transplant. In Hoffman EA, editor, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2709. 1996. p. 55-62
Wu, Qing Hua M D ; McGregor, Christopher G M D ; Wu, Xue Si M D ; Rinaldi, Mauro M D ; Nilsson, Folke N M D ; Tazelaar, Henry D M D ; Ritman, Erik L M D. / Three-dimensional x-ray imaging of the anatomy and function of the lungs and pulmonary arteries in dogs following single lung transplant. Proceedings of SPIE - The International Society for Optical Engineering. editor / Eric A. Hoffman. Vol. 2709 1996. pp. 55-62
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abstract = "It was the goal of this study to see if relatively noninvasive CT studies could provide a quantitative index of acute lung rejection in single lung transplantation. Using volume scanning fast CT, the change in cross-sectional area of the major pulmonary arteries from systole to diastole, regional lung perfusion and ventilation was measured in 12 dogs with left lung allotransplantation before and during rejection and four dogs with left lung autotransplantation. All dogs were anesthetized and scanned in a fast computed tomography scanner (dynamic spatial reconstructor - DSR) during several ventilatory cycles and again during injection of contrast medium into the right atrium. There was significant reduction of regional air content, ventilation, perfusion and pulmonary artery compliance during rejection of the transplanted lung. The severity of these changes related linearly with the histological indices of rejection. It is concluded that minimally invasive dynamic CT imaging of transplanted lung can be used to detect acute rejection and its severity.",
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