Three-dimensional x-ray imaging of the anatomy and function of the lungs and pulmonary arteries in dogs following single lung transplant

Qing Hua M.D. Wu, Christopher G.M.D. McGregor, Xue Si M.D. Wu, Mauro M.D. Rinaldi, Folke N.M.D. Nilsson, Henry D.M.D. Tazelaar, Erik L.M.D. Ritman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

It was the goal of this study to see if relatively noninvasive CT studies could provide a quantitative index of acute lung rejection in single lung transplantation. Using volume scanning fast CT, the change in cross-sectional area of the major pulmonary arteries from systole to diastole, regional lung perfusion and ventilation was measured in 12 dogs with left lung allotransplantation before and during rejection and four dogs with left lung autotransplantation. All dogs were anesthetized and scanned in a fast computed tomography scanner (dynamic spatial reconstructor - DSR) during several ventilatory cycles and again during injection of contrast medium into the right atrium. There was significant reduction of regional air content, ventilation, perfusion and pulmonary artery compliance during rejection of the transplanted lung. The severity of these changes related linearly with the histological indices of rejection. It is concluded that minimally invasive dynamic CT imaging of transplanted lung can be used to detect acute rejection and its severity.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsEric A. Hoffman
Pages55-62
Number of pages8
StatePublished - Jan 1 1996
EventMedical Imaging 1996: Physiology and Function from Multidimensional Images - Newport Beach, CA, USA
Duration: Feb 11 1996Feb 13 1996

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume2709
ISSN (Print)0277-786X

Other

OtherMedical Imaging 1996: Physiology and Function from Multidimensional Images
CityNewport Beach, CA, USA
Period2/11/962/13/96

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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  • Cite this

    Wu, Q. H. M. D., McGregor, C. G. M. D., Wu, X. S. M. D., Rinaldi, M. M. D., Nilsson, F. N. M. D., Tazelaar, H. D. M. D., & Ritman, E. L. M. D. (1996). Three-dimensional x-ray imaging of the anatomy and function of the lungs and pulmonary arteries in dogs following single lung transplant. In E. A. Hoffman (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (pp. 55-62). (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 2709).