Three-Dimensional Volumetric Ultrasound Imaging of Arterial Pathology from Two-Dimensional Intravascular Ultrasound: An in Vitro Study

Krishnaswamy Chandrasekaran, Chandra M. Sehgal, Tsui Lieh Hsu, Nancy A. Young, Arthur J. D’adamo, Richard A. Robb, Natesa G. Pandian

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The objectives of this study were to evaluate: (1) the feasibility of generating three- dimensional (3-D) ultrasound (US) volumetric images of arterial segments from intravascular (IV) US images by retaining full range of gray levels; (2) the feasibility of volumetric quantitation of various arterial wall pathology from the 3-D volume US images of arterial segments. IVUS provides morphologic details of arterial wall diseases. This is seen as variation in gray levels. However, when a 3-D US image is generated currently, the full range of gray levels is not utilized. This limits optimal assessment of arterial wall pathology Sequential cross-sectional IVUS images from 11 arterial segments consisting of various pathology were obtained in vitro by calibrated withdrawal of an IVUS catheter. These images were digitized by an 8 bit digitizer to retain full 256 gray levels of bright ness. 3-D volume generation was carried out using “ANALYZE” software. After the IVUS imaging, arterial segments were sectioned transversely in a 0.3-0.4 mm cross section and stained with hematoxylin, eosin and elastin. Geometrical measurements and gross morphological changes of the arterial segments were noted and correlated with the corre sponding section of the image from the three-dimensional volume. Arterial wall pathology, its extent and its effect on lumen geometry were easily appreciated in multiple tomographic sections of a 3-D volume image. Similarly, arterial wall pathology was easily quantitated from 3-D volume. The above assessments were only feasible by retaining full range of gray levels in the 3-D volume image. This study indicates that (1) it is feasible to generate a 3-D US volume image by retaining full range of gray levels from IVUS images, (2) retaining full range of gray levels allows optimal assessment of arterial wall pathology and its extent in 3-D volume, and (3) IVUS allows quantitation of arterial wall pathology, and thereby one can assess the effect of intervention.

Original languageEnglish (US)
Pages (from-to)253-264
Number of pages12
JournalAngiology
Volume45
Issue number4
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Ultrasonography
Pathology
Three-Dimensional Imaging
Elastin
Hematoxylin
Eosine Yellowish-(YS)
In Vitro Techniques
Software
Catheters

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Chandrasekaran, K., Sehgal, C. M., Hsu, T. L., Young, N. A., D’adamo, A. J., Robb, R. A., & Pandian, N. G. (1994). Three-Dimensional Volumetric Ultrasound Imaging of Arterial Pathology from Two-Dimensional Intravascular Ultrasound: An in Vitro Study. Angiology, 45(4), 253-264. https://doi.org/10.1177/000331979404500401

Three-Dimensional Volumetric Ultrasound Imaging of Arterial Pathology from Two-Dimensional Intravascular Ultrasound : An in Vitro Study. / Chandrasekaran, Krishnaswamy; Sehgal, Chandra M.; Hsu, Tsui Lieh; Young, Nancy A.; D’adamo, Arthur J.; Robb, Richard A.; Pandian, Natesa G.

In: Angiology, Vol. 45, No. 4, 1994, p. 253-264.

Research output: Contribution to journalArticle

Chandrasekaran, K, Sehgal, CM, Hsu, TL, Young, NA, D’adamo, AJ, Robb, RA & Pandian, NG 1994, 'Three-Dimensional Volumetric Ultrasound Imaging of Arterial Pathology from Two-Dimensional Intravascular Ultrasound: An in Vitro Study', Angiology, vol. 45, no. 4, pp. 253-264. https://doi.org/10.1177/000331979404500401
Chandrasekaran, Krishnaswamy ; Sehgal, Chandra M. ; Hsu, Tsui Lieh ; Young, Nancy A. ; D’adamo, Arthur J. ; Robb, Richard A. ; Pandian, Natesa G. / Three-Dimensional Volumetric Ultrasound Imaging of Arterial Pathology from Two-Dimensional Intravascular Ultrasound : An in Vitro Study. In: Angiology. 1994 ; Vol. 45, No. 4. pp. 253-264.
@article{8d6795c73fc343d5adc4f3f062e6bfaf,
title = "Three-Dimensional Volumetric Ultrasound Imaging of Arterial Pathology from Two-Dimensional Intravascular Ultrasound: An in Vitro Study",
abstract = "The objectives of this study were to evaluate: (1) the feasibility of generating three- dimensional (3-D) ultrasound (US) volumetric images of arterial segments from intravascular (IV) US images by retaining full range of gray levels; (2) the feasibility of volumetric quantitation of various arterial wall pathology from the 3-D volume US images of arterial segments. IVUS provides morphologic details of arterial wall diseases. This is seen as variation in gray levels. However, when a 3-D US image is generated currently, the full range of gray levels is not utilized. This limits optimal assessment of arterial wall pathology Sequential cross-sectional IVUS images from 11 arterial segments consisting of various pathology were obtained in vitro by calibrated withdrawal of an IVUS catheter. These images were digitized by an 8 bit digitizer to retain full 256 gray levels of bright ness. 3-D volume generation was carried out using “ANALYZE” software. After the IVUS imaging, arterial segments were sectioned transversely in a 0.3-0.4 mm cross section and stained with hematoxylin, eosin and elastin. Geometrical measurements and gross morphological changes of the arterial segments were noted and correlated with the corre sponding section of the image from the three-dimensional volume. Arterial wall pathology, its extent and its effect on lumen geometry were easily appreciated in multiple tomographic sections of a 3-D volume image. Similarly, arterial wall pathology was easily quantitated from 3-D volume. The above assessments were only feasible by retaining full range of gray levels in the 3-D volume image. This study indicates that (1) it is feasible to generate a 3-D US volume image by retaining full range of gray levels from IVUS images, (2) retaining full range of gray levels allows optimal assessment of arterial wall pathology and its extent in 3-D volume, and (3) IVUS allows quantitation of arterial wall pathology, and thereby one can assess the effect of intervention.",
author = "Krishnaswamy Chandrasekaran and Sehgal, {Chandra M.} and Hsu, {Tsui Lieh} and Young, {Nancy A.} and D’adamo, {Arthur J.} and Robb, {Richard A.} and Pandian, {Natesa G.}",
year = "1994",
doi = "10.1177/000331979404500401",
language = "English (US)",
volume = "45",
pages = "253--264",
journal = "Angiology",
issn = "0003-3197",
publisher = "SAGE Publications Inc.",
number = "4",

}

TY - JOUR

T1 - Three-Dimensional Volumetric Ultrasound Imaging of Arterial Pathology from Two-Dimensional Intravascular Ultrasound

T2 - An in Vitro Study

AU - Chandrasekaran, Krishnaswamy

AU - Sehgal, Chandra M.

AU - Hsu, Tsui Lieh

AU - Young, Nancy A.

AU - D’adamo, Arthur J.

AU - Robb, Richard A.

AU - Pandian, Natesa G.

PY - 1994

Y1 - 1994

N2 - The objectives of this study were to evaluate: (1) the feasibility of generating three- dimensional (3-D) ultrasound (US) volumetric images of arterial segments from intravascular (IV) US images by retaining full range of gray levels; (2) the feasibility of volumetric quantitation of various arterial wall pathology from the 3-D volume US images of arterial segments. IVUS provides morphologic details of arterial wall diseases. This is seen as variation in gray levels. However, when a 3-D US image is generated currently, the full range of gray levels is not utilized. This limits optimal assessment of arterial wall pathology Sequential cross-sectional IVUS images from 11 arterial segments consisting of various pathology were obtained in vitro by calibrated withdrawal of an IVUS catheter. These images were digitized by an 8 bit digitizer to retain full 256 gray levels of bright ness. 3-D volume generation was carried out using “ANALYZE” software. After the IVUS imaging, arterial segments were sectioned transversely in a 0.3-0.4 mm cross section and stained with hematoxylin, eosin and elastin. Geometrical measurements and gross morphological changes of the arterial segments were noted and correlated with the corre sponding section of the image from the three-dimensional volume. Arterial wall pathology, its extent and its effect on lumen geometry were easily appreciated in multiple tomographic sections of a 3-D volume image. Similarly, arterial wall pathology was easily quantitated from 3-D volume. The above assessments were only feasible by retaining full range of gray levels in the 3-D volume image. This study indicates that (1) it is feasible to generate a 3-D US volume image by retaining full range of gray levels from IVUS images, (2) retaining full range of gray levels allows optimal assessment of arterial wall pathology and its extent in 3-D volume, and (3) IVUS allows quantitation of arterial wall pathology, and thereby one can assess the effect of intervention.

AB - The objectives of this study were to evaluate: (1) the feasibility of generating three- dimensional (3-D) ultrasound (US) volumetric images of arterial segments from intravascular (IV) US images by retaining full range of gray levels; (2) the feasibility of volumetric quantitation of various arterial wall pathology from the 3-D volume US images of arterial segments. IVUS provides morphologic details of arterial wall diseases. This is seen as variation in gray levels. However, when a 3-D US image is generated currently, the full range of gray levels is not utilized. This limits optimal assessment of arterial wall pathology Sequential cross-sectional IVUS images from 11 arterial segments consisting of various pathology were obtained in vitro by calibrated withdrawal of an IVUS catheter. These images were digitized by an 8 bit digitizer to retain full 256 gray levels of bright ness. 3-D volume generation was carried out using “ANALYZE” software. After the IVUS imaging, arterial segments were sectioned transversely in a 0.3-0.4 mm cross section and stained with hematoxylin, eosin and elastin. Geometrical measurements and gross morphological changes of the arterial segments were noted and correlated with the corre sponding section of the image from the three-dimensional volume. Arterial wall pathology, its extent and its effect on lumen geometry were easily appreciated in multiple tomographic sections of a 3-D volume image. Similarly, arterial wall pathology was easily quantitated from 3-D volume. The above assessments were only feasible by retaining full range of gray levels in the 3-D volume image. This study indicates that (1) it is feasible to generate a 3-D US volume image by retaining full range of gray levels from IVUS images, (2) retaining full range of gray levels allows optimal assessment of arterial wall pathology and its extent in 3-D volume, and (3) IVUS allows quantitation of arterial wall pathology, and thereby one can assess the effect of intervention.

UR - http://www.scopus.com/inward/record.url?scp=0028207126&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028207126&partnerID=8YFLogxK

U2 - 10.1177/000331979404500401

DO - 10.1177/000331979404500401

M3 - Article

C2 - 8161003

AN - SCOPUS:0028207126

VL - 45

SP - 253

EP - 264

JO - Angiology

JF - Angiology

SN - 0003-3197

IS - 4

ER -