TY - JOUR
T1 - Three-dimensional ultrasonographic assessment of fetal lung volume as prognostic factor in isolated congenital diaphragmatic hernia
AU - Ruano, Rodrigo
AU - Benachi, Alexandra
AU - Joubin, Laurence
AU - Aubry, Marie Cécile
AU - Thalabard, Jean Christophe
AU - Dumez, Yves
AU - Dommergues, Marc
PY - 2004/5
Y1 - 2004/5
N2 - Objective: To evaluate the potential of three-dimensional ultrasound to predict outcome in congenital diaphragmatic hernia. Design: Prospective observational study. Setting: Tertiary care centre. Population: Twelve cases of isolated congenital diaphragmatic hernia (11 left-sided, 1 right-sided) and 109 controls. Methods: Fetal lung volume was assessed by three-dimensional ultrasound using the technique of rotation of the multiplanar imaging. In the control fetuses, a logistic transformation was performed to correlate fetal lung volume with gestational age, and the confidence interval was obtained with a bootstrap resampling. A mathematical equation was then obtained allowing calculation of the expected fetal lung volume as a function of gestational age. In fetuses with congenital diaphragmatic hernia, the observed/expected lung volume ratio was compared with postnatal outcome. Main outcome measures: Neonatal mortality and pulmonary hypoplasia, which was defined as lung/body weight ratios less than 0.012. Results: The expected fetal lung volume was derived from the mathematical equation: Fetal lung volume (mL) = exp(4.72/(1 + exp((20.32 - gestational age in weeks) / 6.05))). The observed/expected fetal lung volume ratio was significantly lower in the congenital diaphragmatic hernia group (median: 0.34, range: 0.16-0.66), than in the control group (median: 1.02, range: 0.62-1.97, P < 0.0001). The distribution of this ratio was significantly downshifted in the infants with congenital diaphragmatic hernia who died (median: 0.19, range: 0.18-0.66) compared with survivors (median: 0.44, range: 0.36-0.66, P = 0.04). The observed/expected fetal lung volume ratio was also correlated with the postmortem lung/body weight ratio. Conclusion: In isolated congenital diaphragmatic hernia, fetal lung volume measurement by three-dimensional ultrasound is a potential predictor for pulmonary hypoplasia and postnatal outcome.
AB - Objective: To evaluate the potential of three-dimensional ultrasound to predict outcome in congenital diaphragmatic hernia. Design: Prospective observational study. Setting: Tertiary care centre. Population: Twelve cases of isolated congenital diaphragmatic hernia (11 left-sided, 1 right-sided) and 109 controls. Methods: Fetal lung volume was assessed by three-dimensional ultrasound using the technique of rotation of the multiplanar imaging. In the control fetuses, a logistic transformation was performed to correlate fetal lung volume with gestational age, and the confidence interval was obtained with a bootstrap resampling. A mathematical equation was then obtained allowing calculation of the expected fetal lung volume as a function of gestational age. In fetuses with congenital diaphragmatic hernia, the observed/expected lung volume ratio was compared with postnatal outcome. Main outcome measures: Neonatal mortality and pulmonary hypoplasia, which was defined as lung/body weight ratios less than 0.012. Results: The expected fetal lung volume was derived from the mathematical equation: Fetal lung volume (mL) = exp(4.72/(1 + exp((20.32 - gestational age in weeks) / 6.05))). The observed/expected fetal lung volume ratio was significantly lower in the congenital diaphragmatic hernia group (median: 0.34, range: 0.16-0.66), than in the control group (median: 1.02, range: 0.62-1.97, P < 0.0001). The distribution of this ratio was significantly downshifted in the infants with congenital diaphragmatic hernia who died (median: 0.19, range: 0.18-0.66) compared with survivors (median: 0.44, range: 0.36-0.66, P = 0.04). The observed/expected fetal lung volume ratio was also correlated with the postmortem lung/body weight ratio. Conclusion: In isolated congenital diaphragmatic hernia, fetal lung volume measurement by three-dimensional ultrasound is a potential predictor for pulmonary hypoplasia and postnatal outcome.
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U2 - 10.1111/j.1471-0528.2004.00100.x
DO - 10.1111/j.1471-0528.2004.00100.x
M3 - Article
C2 - 15104604
AN - SCOPUS:2442625587
SN - 1470-0328
VL - 111
SP - 423
EP - 429
JO - BJOG: An International Journal of Obstetrics and Gynaecology
JF - BJOG: An International Journal of Obstetrics and Gynaecology
IS - 5
ER -