Three-dimensional sonographic measurement of contralateral lung volume in fetuses with isolated congenital diaphragmatic hernia

Rodrigo Ruano, Marie Cécile Aubry, Bruno Barthe, Yves Dumez, Marcelo Zugaib, Alexandra Benachi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Purpose. To use 3-dimensional sonography (3DUS) to measure contralateral lung volume and evaluate the potential of this measurement to predict neonatal outcome in isolated congenital diaphragmatic hernia (CDH). Methods. Between January 2002 and December 2004, the contralateral lung volumes of 39 fetuses with isolated CDH were measured via 3DUS using rotational multiplanar imaging. The observed/expected contralateral fetal lung volume ratios (o/e-ContFLVR) were compared with the lung/head ratio (LHR), observed/expected total fetal lung volume ratio (o/e-TotFLVR), and postnatal outcome. Results. Contralateral lung volumes are less reduced than total lung volumes in CDH. The bias and precision of 3DUS in estimating contralateral lung volumes were 0.99 cm3 and 1.11 cm3, respectively, with absolute limits of agreement ranging from -1.19 cm3 to +3.17 cm3. The o/e-ContFLVR was significantly lower in neonatal death cases (median, 0.49 cm3; range, 0.22-0.99 cm3) than in survival cases (median, 0.58 cm3; range, 0.42-0.92 cm3 [p < 0.01]). Overall accuracy of the o/e-ContFLVR, o/e-TotFLVR, and LHR in predicting neonatal death were 67.7% (21/31), 80.7% (25/31), and 77.4% (24/31), respectively. Conclusion. Although o/e-ContFLVR can be precisely measured with 3DUS and can be used to predict neonatal death in CDH, it is less accurate than LHR and o/e-TotFLVR for that purpose.

Original languageEnglish (US)
Pages (from-to)273-278
Number of pages6
JournalJournal of Clinical Ultrasound
Volume36
Issue number5
DOIs
StatePublished - Jun 1 2008
Externally publishedYes

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Lung Volume Measurements
Fetus
Lung
Head
Congenital Diaphragmatic Hernias

Keywords

  • 3-dimensional ultrasonography
  • Congenital diaphragmatic hernia
  • Fetal malformations
  • Prenatal diagnosis
  • Pulmonary hypoplasia
  • Ultrasonography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Three-dimensional sonographic measurement of contralateral lung volume in fetuses with isolated congenital diaphragmatic hernia. / Ruano, Rodrigo; Aubry, Marie Cécile; Barthe, Bruno; Dumez, Yves; Zugaib, Marcelo; Benachi, Alexandra.

In: Journal of Clinical Ultrasound, Vol. 36, No. 5, 01.06.2008, p. 273-278.

Research output: Contribution to journalArticle

Ruano, Rodrigo ; Aubry, Marie Cécile ; Barthe, Bruno ; Dumez, Yves ; Zugaib, Marcelo ; Benachi, Alexandra. / Three-dimensional sonographic measurement of contralateral lung volume in fetuses with isolated congenital diaphragmatic hernia. In: Journal of Clinical Ultrasound. 2008 ; Vol. 36, No. 5. pp. 273-278.
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abstract = "Purpose. To use 3-dimensional sonography (3DUS) to measure contralateral lung volume and evaluate the potential of this measurement to predict neonatal outcome in isolated congenital diaphragmatic hernia (CDH). Methods. Between January 2002 and December 2004, the contralateral lung volumes of 39 fetuses with isolated CDH were measured via 3DUS using rotational multiplanar imaging. The observed/expected contralateral fetal lung volume ratios (o/e-ContFLVR) were compared with the lung/head ratio (LHR), observed/expected total fetal lung volume ratio (o/e-TotFLVR), and postnatal outcome. Results. Contralateral lung volumes are less reduced than total lung volumes in CDH. The bias and precision of 3DUS in estimating contralateral lung volumes were 0.99 cm3 and 1.11 cm3, respectively, with absolute limits of agreement ranging from -1.19 cm3 to +3.17 cm3. The o/e-ContFLVR was significantly lower in neonatal death cases (median, 0.49 cm3; range, 0.22-0.99 cm3) than in survival cases (median, 0.58 cm3; range, 0.42-0.92 cm3 [p < 0.01]). Overall accuracy of the o/e-ContFLVR, o/e-TotFLVR, and LHR in predicting neonatal death were 67.7{\%} (21/31), 80.7{\%} (25/31), and 77.4{\%} (24/31), respectively. Conclusion. Although o/e-ContFLVR can be precisely measured with 3DUS and can be used to predict neonatal death in CDH, it is less accurate than LHR and o/e-TotFLVR for that purpose.",
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AU - Ruano, Rodrigo

AU - Aubry, Marie Cécile

AU - Barthe, Bruno

AU - Dumez, Yves

AU - Zugaib, Marcelo

AU - Benachi, Alexandra

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N2 - Purpose. To use 3-dimensional sonography (3DUS) to measure contralateral lung volume and evaluate the potential of this measurement to predict neonatal outcome in isolated congenital diaphragmatic hernia (CDH). Methods. Between January 2002 and December 2004, the contralateral lung volumes of 39 fetuses with isolated CDH were measured via 3DUS using rotational multiplanar imaging. The observed/expected contralateral fetal lung volume ratios (o/e-ContFLVR) were compared with the lung/head ratio (LHR), observed/expected total fetal lung volume ratio (o/e-TotFLVR), and postnatal outcome. Results. Contralateral lung volumes are less reduced than total lung volumes in CDH. The bias and precision of 3DUS in estimating contralateral lung volumes were 0.99 cm3 and 1.11 cm3, respectively, with absolute limits of agreement ranging from -1.19 cm3 to +3.17 cm3. The o/e-ContFLVR was significantly lower in neonatal death cases (median, 0.49 cm3; range, 0.22-0.99 cm3) than in survival cases (median, 0.58 cm3; range, 0.42-0.92 cm3 [p < 0.01]). Overall accuracy of the o/e-ContFLVR, o/e-TotFLVR, and LHR in predicting neonatal death were 67.7% (21/31), 80.7% (25/31), and 77.4% (24/31), respectively. Conclusion. Although o/e-ContFLVR can be precisely measured with 3DUS and can be used to predict neonatal death in CDH, it is less accurate than LHR and o/e-TotFLVR for that purpose.

AB - Purpose. To use 3-dimensional sonography (3DUS) to measure contralateral lung volume and evaluate the potential of this measurement to predict neonatal outcome in isolated congenital diaphragmatic hernia (CDH). Methods. Between January 2002 and December 2004, the contralateral lung volumes of 39 fetuses with isolated CDH were measured via 3DUS using rotational multiplanar imaging. The observed/expected contralateral fetal lung volume ratios (o/e-ContFLVR) were compared with the lung/head ratio (LHR), observed/expected total fetal lung volume ratio (o/e-TotFLVR), and postnatal outcome. Results. Contralateral lung volumes are less reduced than total lung volumes in CDH. The bias and precision of 3DUS in estimating contralateral lung volumes were 0.99 cm3 and 1.11 cm3, respectively, with absolute limits of agreement ranging from -1.19 cm3 to +3.17 cm3. The o/e-ContFLVR was significantly lower in neonatal death cases (median, 0.49 cm3; range, 0.22-0.99 cm3) than in survival cases (median, 0.58 cm3; range, 0.42-0.92 cm3 [p < 0.01]). Overall accuracy of the o/e-ContFLVR, o/e-TotFLVR, and LHR in predicting neonatal death were 67.7% (21/31), 80.7% (25/31), and 77.4% (24/31), respectively. Conclusion. Although o/e-ContFLVR can be precisely measured with 3DUS and can be used to predict neonatal death in CDH, it is less accurate than LHR and o/e-TotFLVR for that purpose.

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KW - Prenatal diagnosis

KW - Pulmonary hypoplasia

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