Three-dimensional shear wave elastography for differentiation of breast lesions

An initial study with quantitative analysis using three orthogonal planes

Qiao Wang, Xiao Long Li, Ya Ping He, Azra Alizad, Shigao D Chen, Chong Ke Zhao, Le Hang Guo, Xiao Wan Bo, Wei Wei Ren, Bang Guo Zhou, Hui Xiong Xu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

OBJECTIVES: To prospectively evaluate the diagnostic performance of three-dimensional (3D) shear wave elastography (SWE) for breast lesions with quantitative stiffness information from transverse, sagittal and coronal planes. METHODS: Conventional ultrasound (US), two-dimensional (2D)-SWE and 3D-SWE were performed for 122 consecutive patients with 122 breast lesions before biopsy or surgical excision. Maximum elasticity values of Young's modulus (Emax) were recorded on 2D-SWE and three planes of 3D-SWE. Area under the receiver operating characteristic curve (AUC), sensitivity and specificity of US, 2D-SWE and 3D-SWE were evaluated. Two combined sets (i.e., BI-RADS and 2D-SWE; BI-RADS and 3D-SWE) were compared in AUC. Observer consistency was also evaluated. RESULTS: On 3D-SWE, the AUC and sensitivity of sagittal plane were significantly higher than those of transverse and coronal planes (both P < 0.05). Compared with BI-RADS alone, both combined sets had significantly (P < 0.05) higher AUCs and specificities, whereas, the two combined sets showed no significant difference in AUC (P > 0.05). However, the combined set of BI-RADS and sagittal plane of 3D-SWE had significantly higher sensitivity than the combined set of BI-RADS and 2D-SWE. CONCLUSIONS: The sagittal plane shows the best diagnostic performance among 3D-SWE. The combination of BI-RADS and 3D-SWE is a useful tool for predicting breast malignant lesions in comparison with BI-RADS alone.

Original languageEnglish (US)
Pages (from-to)311-324
Number of pages14
JournalClinical Hemorheology and Microcirculation
Volume71
Issue number3
DOIs
StatePublished - Jan 1 2019

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Elasticity Imaging Techniques
Breast
Area Under Curve
Elastic Modulus
Elasticity
ROC Curve

Keywords

  • Breast
  • Quantitative analysis
  • Shear wave elastography
  • Three-dimensional
  • Ultrasound

ASJC Scopus subject areas

  • Physiology
  • Hematology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Three-dimensional shear wave elastography for differentiation of breast lesions : An initial study with quantitative analysis using three orthogonal planes. / Wang, Qiao; Li, Xiao Long; He, Ya Ping; Alizad, Azra; Chen, Shigao D; Zhao, Chong Ke; Guo, Le Hang; Bo, Xiao Wan; Ren, Wei Wei; Zhou, Bang Guo; Xu, Hui Xiong.

In: Clinical Hemorheology and Microcirculation, Vol. 71, No. 3, 01.01.2019, p. 311-324.

Research output: Contribution to journalArticle

Wang, Qiao ; Li, Xiao Long ; He, Ya Ping ; Alizad, Azra ; Chen, Shigao D ; Zhao, Chong Ke ; Guo, Le Hang ; Bo, Xiao Wan ; Ren, Wei Wei ; Zhou, Bang Guo ; Xu, Hui Xiong. / Three-dimensional shear wave elastography for differentiation of breast lesions : An initial study with quantitative analysis using three orthogonal planes. In: Clinical Hemorheology and Microcirculation. 2019 ; Vol. 71, No. 3. pp. 311-324.
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abstract = "OBJECTIVES: To prospectively evaluate the diagnostic performance of three-dimensional (3D) shear wave elastography (SWE) for breast lesions with quantitative stiffness information from transverse, sagittal and coronal planes. METHODS: Conventional ultrasound (US), two-dimensional (2D)-SWE and 3D-SWE were performed for 122 consecutive patients with 122 breast lesions before biopsy or surgical excision. Maximum elasticity values of Young's modulus (Emax) were recorded on 2D-SWE and three planes of 3D-SWE. Area under the receiver operating characteristic curve (AUC), sensitivity and specificity of US, 2D-SWE and 3D-SWE were evaluated. Two combined sets (i.e., BI-RADS and 2D-SWE; BI-RADS and 3D-SWE) were compared in AUC. Observer consistency was also evaluated. RESULTS: On 3D-SWE, the AUC and sensitivity of sagittal plane were significantly higher than those of transverse and coronal planes (both P < 0.05). Compared with BI-RADS alone, both combined sets had significantly (P < 0.05) higher AUCs and specificities, whereas, the two combined sets showed no significant difference in AUC (P > 0.05). However, the combined set of BI-RADS and sagittal plane of 3D-SWE had significantly higher sensitivity than the combined set of BI-RADS and 2D-SWE. CONCLUSIONS: The sagittal plane shows the best diagnostic performance among 3D-SWE. The combination of BI-RADS and 3D-SWE is a useful tool for predicting breast malignant lesions in comparison with BI-RADS alone.",
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T1 - Three-dimensional shear wave elastography for differentiation of breast lesions

T2 - An initial study with quantitative analysis using three orthogonal planes

AU - Wang, Qiao

AU - Li, Xiao Long

AU - He, Ya Ping

AU - Alizad, Azra

AU - Chen, Shigao D

AU - Zhao, Chong Ke

AU - Guo, Le Hang

AU - Bo, Xiao Wan

AU - Ren, Wei Wei

AU - Zhou, Bang Guo

AU - Xu, Hui Xiong

PY - 2019/1/1

Y1 - 2019/1/1

N2 - OBJECTIVES: To prospectively evaluate the diagnostic performance of three-dimensional (3D) shear wave elastography (SWE) for breast lesions with quantitative stiffness information from transverse, sagittal and coronal planes. METHODS: Conventional ultrasound (US), two-dimensional (2D)-SWE and 3D-SWE were performed for 122 consecutive patients with 122 breast lesions before biopsy or surgical excision. Maximum elasticity values of Young's modulus (Emax) were recorded on 2D-SWE and three planes of 3D-SWE. Area under the receiver operating characteristic curve (AUC), sensitivity and specificity of US, 2D-SWE and 3D-SWE were evaluated. Two combined sets (i.e., BI-RADS and 2D-SWE; BI-RADS and 3D-SWE) were compared in AUC. Observer consistency was also evaluated. RESULTS: On 3D-SWE, the AUC and sensitivity of sagittal plane were significantly higher than those of transverse and coronal planes (both P < 0.05). Compared with BI-RADS alone, both combined sets had significantly (P < 0.05) higher AUCs and specificities, whereas, the two combined sets showed no significant difference in AUC (P > 0.05). However, the combined set of BI-RADS and sagittal plane of 3D-SWE had significantly higher sensitivity than the combined set of BI-RADS and 2D-SWE. CONCLUSIONS: The sagittal plane shows the best diagnostic performance among 3D-SWE. The combination of BI-RADS and 3D-SWE is a useful tool for predicting breast malignant lesions in comparison with BI-RADS alone.

AB - OBJECTIVES: To prospectively evaluate the diagnostic performance of three-dimensional (3D) shear wave elastography (SWE) for breast lesions with quantitative stiffness information from transverse, sagittal and coronal planes. METHODS: Conventional ultrasound (US), two-dimensional (2D)-SWE and 3D-SWE were performed for 122 consecutive patients with 122 breast lesions before biopsy or surgical excision. Maximum elasticity values of Young's modulus (Emax) were recorded on 2D-SWE and three planes of 3D-SWE. Area under the receiver operating characteristic curve (AUC), sensitivity and specificity of US, 2D-SWE and 3D-SWE were evaluated. Two combined sets (i.e., BI-RADS and 2D-SWE; BI-RADS and 3D-SWE) were compared in AUC. Observer consistency was also evaluated. RESULTS: On 3D-SWE, the AUC and sensitivity of sagittal plane were significantly higher than those of transverse and coronal planes (both P < 0.05). Compared with BI-RADS alone, both combined sets had significantly (P < 0.05) higher AUCs and specificities, whereas, the two combined sets showed no significant difference in AUC (P > 0.05). However, the combined set of BI-RADS and sagittal plane of 3D-SWE had significantly higher sensitivity than the combined set of BI-RADS and 2D-SWE. CONCLUSIONS: The sagittal plane shows the best diagnostic performance among 3D-SWE. The combination of BI-RADS and 3D-SWE is a useful tool for predicting breast malignant lesions in comparison with BI-RADS alone.

KW - Breast

KW - Quantitative analysis

KW - Shear wave elastography

KW - Three-dimensional

KW - Ultrasound

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