Three-dimensional shear wave elastography for differentiating benign from malignant thyroid nodules

Chong Ke Zhao, Shigao D Chen, Azra Alizad, Ya Ping He, Qiao Wang, Dan Wang, Wen Wen Yue, Kun Zhang, Shen Qu, Qing Wei, Hui Xiong Xu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives—To prospectively evaluate the diagnostic performance of 3-dimensional (3D) shear wave elastography (SWE) for assessing thyroid nodules. Methods—A total of 176 surgically or cytologically confirmed thyroid nodules (63 malignant and 113 benign) in 176 patients who had undergone conventional ultrasound (US), 2-dimensional (2D) SWE, and 3D SWE examinations were included in this study. Quantitative elasticity values (mean elasticity, maximum elasticity, and standard deviation of elasticity of a large region of interest and mean elasticity of a 2-mm region of interest) were measured on 2D and 3D SWE. Diagnostic performances of conventional US, 2D SWE, and 3D SWE were assessed. The role of 2D and 3D SWE in reducing unnecessary fine-needle aspiration (FNA) for nodules with low suspicion was also evaluated. Results—The diagnostic performances in terms of the area under the receiver operating characteristic curve were 0.612 for conventional US, 0.836 for 2D SWE (P<.001 in comparison with conventional US), and 0.839 for 3D SWE (P<.001 in comparison with conventional US). The mean elasticity achieved the highest diagnostic performance in 2D SWE, whereas the standard deviation of elasticity achieved the highest performance in 3D SWE, although no significant difference was found between them (P>.05). Three-dimensional SWE increased the specificity in comparison with 2D SWE (88.5% versus 82.3%; P5.039). For the 37 nodules with low suspicion on conventional US imaging, 2D SWE was able to avoid unnecessary FNA in 77.1% (27 of 35) of benign nodules, and 3D SWE further increased the number to 88.6% (31 of 35). Conclusions—Three-dimensional SWE is a useful tool for predicting thyroid nodule malignancy and reducing unnecessary FNA procedures in thyroid nodules with low suspicion of malignancy.

Original languageEnglish (US)
Pages (from-to)1777-1788
Number of pages12
JournalJournal of Ultrasound in Medicine
Volume37
Issue number7
DOIs
StatePublished - Jan 1 2018

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Elasticity Imaging Techniques
Thyroid Nodule
Elasticity
Fine Needle Biopsy
ROC Curve

Keywords

  • 3-dimensional
  • Elastography
  • Head and neck
  • Shear wave elastography
  • Thyroid nodule
  • Thyroid/parathyroid
  • Ultrasound

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

Three-dimensional shear wave elastography for differentiating benign from malignant thyroid nodules. / Zhao, Chong Ke; Chen, Shigao D; Alizad, Azra; He, Ya Ping; Wang, Qiao; Wang, Dan; Yue, Wen Wen; Zhang, Kun; Qu, Shen; Wei, Qing; Xu, Hui Xiong.

In: Journal of Ultrasound in Medicine, Vol. 37, No. 7, 01.01.2018, p. 1777-1788.

Research output: Contribution to journalArticle

Zhao, Chong Ke ; Chen, Shigao D ; Alizad, Azra ; He, Ya Ping ; Wang, Qiao ; Wang, Dan ; Yue, Wen Wen ; Zhang, Kun ; Qu, Shen ; Wei, Qing ; Xu, Hui Xiong. / Three-dimensional shear wave elastography for differentiating benign from malignant thyroid nodules. In: Journal of Ultrasound in Medicine. 2018 ; Vol. 37, No. 7. pp. 1777-1788.
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abstract = "Objectives—To prospectively evaluate the diagnostic performance of 3-dimensional (3D) shear wave elastography (SWE) for assessing thyroid nodules. Methods—A total of 176 surgically or cytologically confirmed thyroid nodules (63 malignant and 113 benign) in 176 patients who had undergone conventional ultrasound (US), 2-dimensional (2D) SWE, and 3D SWE examinations were included in this study. Quantitative elasticity values (mean elasticity, maximum elasticity, and standard deviation of elasticity of a large region of interest and mean elasticity of a 2-mm region of interest) were measured on 2D and 3D SWE. Diagnostic performances of conventional US, 2D SWE, and 3D SWE were assessed. The role of 2D and 3D SWE in reducing unnecessary fine-needle aspiration (FNA) for nodules with low suspicion was also evaluated. Results—The diagnostic performances in terms of the area under the receiver operating characteristic curve were 0.612 for conventional US, 0.836 for 2D SWE (P<.001 in comparison with conventional US), and 0.839 for 3D SWE (P<.001 in comparison with conventional US). The mean elasticity achieved the highest diagnostic performance in 2D SWE, whereas the standard deviation of elasticity achieved the highest performance in 3D SWE, although no significant difference was found between them (P>.05). Three-dimensional SWE increased the specificity in comparison with 2D SWE (88.5{\%} versus 82.3{\%}; P5.039). For the 37 nodules with low suspicion on conventional US imaging, 2D SWE was able to avoid unnecessary FNA in 77.1{\%} (27 of 35) of benign nodules, and 3D SWE further increased the number to 88.6{\%} (31 of 35). Conclusions—Three-dimensional SWE is a useful tool for predicting thyroid nodule malignancy and reducing unnecessary FNA procedures in thyroid nodules with low suspicion of malignancy.",
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T1 - Three-dimensional shear wave elastography for differentiating benign from malignant thyroid nodules

AU - Zhao, Chong Ke

AU - Chen, Shigao D

AU - Alizad, Azra

AU - He, Ya Ping

AU - Wang, Qiao

AU - Wang, Dan

AU - Yue, Wen Wen

AU - Zhang, Kun

AU - Qu, Shen

AU - Wei, Qing

AU - Xu, Hui Xiong

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objectives—To prospectively evaluate the diagnostic performance of 3-dimensional (3D) shear wave elastography (SWE) for assessing thyroid nodules. Methods—A total of 176 surgically or cytologically confirmed thyroid nodules (63 malignant and 113 benign) in 176 patients who had undergone conventional ultrasound (US), 2-dimensional (2D) SWE, and 3D SWE examinations were included in this study. Quantitative elasticity values (mean elasticity, maximum elasticity, and standard deviation of elasticity of a large region of interest and mean elasticity of a 2-mm region of interest) were measured on 2D and 3D SWE. Diagnostic performances of conventional US, 2D SWE, and 3D SWE were assessed. The role of 2D and 3D SWE in reducing unnecessary fine-needle aspiration (FNA) for nodules with low suspicion was also evaluated. Results—The diagnostic performances in terms of the area under the receiver operating characteristic curve were 0.612 for conventional US, 0.836 for 2D SWE (P<.001 in comparison with conventional US), and 0.839 for 3D SWE (P<.001 in comparison with conventional US). The mean elasticity achieved the highest diagnostic performance in 2D SWE, whereas the standard deviation of elasticity achieved the highest performance in 3D SWE, although no significant difference was found between them (P>.05). Three-dimensional SWE increased the specificity in comparison with 2D SWE (88.5% versus 82.3%; P5.039). For the 37 nodules with low suspicion on conventional US imaging, 2D SWE was able to avoid unnecessary FNA in 77.1% (27 of 35) of benign nodules, and 3D SWE further increased the number to 88.6% (31 of 35). Conclusions—Three-dimensional SWE is a useful tool for predicting thyroid nodule malignancy and reducing unnecessary FNA procedures in thyroid nodules with low suspicion of malignancy.

AB - Objectives—To prospectively evaluate the diagnostic performance of 3-dimensional (3D) shear wave elastography (SWE) for assessing thyroid nodules. Methods—A total of 176 surgically or cytologically confirmed thyroid nodules (63 malignant and 113 benign) in 176 patients who had undergone conventional ultrasound (US), 2-dimensional (2D) SWE, and 3D SWE examinations were included in this study. Quantitative elasticity values (mean elasticity, maximum elasticity, and standard deviation of elasticity of a large region of interest and mean elasticity of a 2-mm region of interest) were measured on 2D and 3D SWE. Diagnostic performances of conventional US, 2D SWE, and 3D SWE were assessed. The role of 2D and 3D SWE in reducing unnecessary fine-needle aspiration (FNA) for nodules with low suspicion was also evaluated. Results—The diagnostic performances in terms of the area under the receiver operating characteristic curve were 0.612 for conventional US, 0.836 for 2D SWE (P<.001 in comparison with conventional US), and 0.839 for 3D SWE (P<.001 in comparison with conventional US). The mean elasticity achieved the highest diagnostic performance in 2D SWE, whereas the standard deviation of elasticity achieved the highest performance in 3D SWE, although no significant difference was found between them (P>.05). Three-dimensional SWE increased the specificity in comparison with 2D SWE (88.5% versus 82.3%; P5.039). For the 37 nodules with low suspicion on conventional US imaging, 2D SWE was able to avoid unnecessary FNA in 77.1% (27 of 35) of benign nodules, and 3D SWE further increased the number to 88.6% (31 of 35). Conclusions—Three-dimensional SWE is a useful tool for predicting thyroid nodule malignancy and reducing unnecessary FNA procedures in thyroid nodules with low suspicion of malignancy.

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KW - Head and neck

KW - Shear wave elastography

KW - Thyroid nodule

KW - Thyroid/parathyroid

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