Three dimensional in vitro mechanical model for bone formation

A. C. Jen, S. L. Ishaug, M. J. Yaszemski, L. V. McIntire, A. G. Mikos

Research output: Contribution to conferencePaper

1 Scopus citations

Abstract

A three dimensional in vitro model was developed to study the effects of mechanical stimuli on bone formation. The model takes advantage of the simplicity of cell culture with an isolated cell population which allows the investigation of the cellular and molecular mechanisms while maintaining the natural architecture of bone. Three dimensional polymer/cell cultures were subjected to controlled compression to simulate mechanical loading conditions, and bone formation was monitored by cellular activity and structural observation, confocal microscopy and histology.

Original languageEnglish (US)
Number of pages1
StatePublished - Dec 1 1996
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

ASJC Scopus subject areas

  • Materials Science(all)

Fingerprint Dive into the research topics of 'Three dimensional in vitro mechanical model for bone formation'. Together they form a unique fingerprint.

  • Cite this

    Jen, A. C., Ishaug, S. L., Yaszemski, M. J., McIntire, L. V., & Mikos, A. G. (1996). Three dimensional in vitro mechanical model for bone formation. Paper presented at Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, .