Three dimensional in vitro mechanical model for bone formation

A. C. Jen; S. L. Ishaug; M. J. Yaszemski; L. V. McIntire; A. G. Mikos

Three dimensional in vitro mechanical model for bone formation

A. C. Jen, S. L. Ishaug, M. J. Yaszemski, L. V. McIntire, A. G. Mikos

Orthopedic Surgery

Research output: Contribution to conference › Paper › peer-review

1 Scopus citations

Abstract

A three dimensional in vitro model was developed to study the effects of mechanical stimuli on bone formation. The model takes advantage of the simplicity of cell culture with an isolated cell population which allows the investigation of the cellular and molecular mechanisms while maintaining the natural architecture of bone. Three dimensional polymer/cell cultures were subjected to controlled compression to simulate mechanical loading conditions, and bone formation was monitored by cellular activity and structural observation, confocal microscopy and histology.

Original language	English (US)
Number of pages	1
State	Published - Dec 1 1996
Event	Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can Duration: May 29 1996 → Jun 2 1996

Other

Other	Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
City	Toronto, Can
Period	5/29/96 → 6/2/96

ASJC Scopus subject areas

Materials Science(all)

Cite this

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title = "Three dimensional in vitro mechanical model for bone formation",

abstract = "A three dimensional in vitro model was developed to study the effects of mechanical stimuli on bone formation. The model takes advantage of the simplicity of cell culture with an isolated cell population which allows the investigation of the cellular and molecular mechanisms while maintaining the natural architecture of bone. Three dimensional polymer/cell cultures were subjected to controlled compression to simulate mechanical loading conditions, and bone formation was monitored by cellular activity and structural observation, confocal microscopy and histology.",

author = "Jen, {A. C.} and Ishaug, {S. L.} and Yaszemski, {M. J.} and McIntire, {L. V.} and Mikos, {A. G.}",

year = "1996",

month = dec,

day = "1",

language = "English (US)",

note = "Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) ; Conference date: 29-05-1996 Through 02-06-1996",

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TY - CONF

T1 - Three dimensional in vitro mechanical model for bone formation

AU - Jen, A. C.

AU - Ishaug, S. L.

AU - Yaszemski, M. J.

AU - McIntire, L. V.

AU - Mikos, A. G.

PY - 1996/12/1

Y1 - 1996/12/1

N2 - A three dimensional in vitro model was developed to study the effects of mechanical stimuli on bone formation. The model takes advantage of the simplicity of cell culture with an isolated cell population which allows the investigation of the cellular and molecular mechanisms while maintaining the natural architecture of bone. Three dimensional polymer/cell cultures were subjected to controlled compression to simulate mechanical loading conditions, and bone formation was monitored by cellular activity and structural observation, confocal microscopy and histology.

AB - A three dimensional in vitro model was developed to study the effects of mechanical stimuli on bone formation. The model takes advantage of the simplicity of cell culture with an isolated cell population which allows the investigation of the cellular and molecular mechanisms while maintaining the natural architecture of bone. Three dimensional polymer/cell cultures were subjected to controlled compression to simulate mechanical loading conditions, and bone formation was monitored by cellular activity and structural observation, confocal microscopy and histology.

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M3 - Paper

AN - SCOPUS:0030385454

T2 - Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)

Y2 - 29 May 1996 through 2 June 1996

ER -

Three dimensional in vitro mechanical model for bone formation

Abstract

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ASJC Scopus subject areas

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