Thio-isoglobotrihexosylceramide, an agonist for activating invariant natural killer T cells

Chengfeng Xia, Dapeng Zhou, Chengwen Liu, Yanyan Lou, Qingjia Yao, Wenpeng Zhang, Peng George Wang

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Thio-isoglobotrihexosylceramide (S-iGb3) might be resistant to α-galactosidases in antigen-presenting cells and have a longer retaining time in the lysosome before being loaded to CD1d. The biological assay showed that S-iGb3 demonstrates a much higher increase as a stimulatory ligand toward invariant natural killer T (iNKT) cells as compared to iGb3.

Original languageEnglish (US)
Pages (from-to)5493-5496
Number of pages4
JournalOrganic Letters
Volume8
Issue number24
DOIs
StatePublished - Nov 23 2006

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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