Thermoregulation in Parkinson disease

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Autonomic dysfunction in Parkinson disease encompasses thermoregulatory symptoms and was first noted by Gowers in the late 19th century when he described abnormal temperature sensation and sweating in Parkinson disease patients. These thermoregulatory symptoms became more recognized in the postlevodopa era when Parkinson disease patients were more readily tested with objective autonomic function tests. Objective thermoregulatory testing in Parkinson disease reveals deficits of sweating and vasomotor tone which often correlate with the severity of other autonomic deficits. Tests of thermoregulatory function can also be used to differentiate Parkinson disease from other neurodegenerative disorders. The pathophysiology of thermoregulatory dysfunction in Parkinson disease encompasses both central and peripheral mechanisms; involvement of the brainstem and hypothalamus with alpha-synuclein pathology is well recognized with increasing evidence of peripheral neuropathy in Parkinson disease that influences thermoregulation. Medications used to treat Parkinson disease also affect thermoregulatory symptoms. Disorders of thermoregulation significantly affect the quality of life for patients and their caregivers and can be severe and even life threatening, such as in the parkinsonism-hyperpyrexia syndrome.

Original languageEnglish (US)
Title of host publicationHandbook of Clinical Neurology
PublisherElsevier B.V.
Pages715-725
Number of pages11
DOIs
StatePublished - Jan 1 2018

Publication series

NameHandbook of Clinical Neurology
Volume157
ISSN (Print)0072-9752
ISSN (Electronic)2212-4152

Fingerprint

Body Temperature Regulation
Parkinson Disease
Sweating
alpha-Synuclein
Parkinsonian Disorders
Peripheral Nervous System Diseases
Neurodegenerative Diseases
Caregivers
Hypothalamus
Brain Stem
Quality of Life
Pathology
Temperature

Keywords

  • autonomic
  • hyperhidrosis
  • Parkinson disease
  • parkinsonism-hyperpyrexia
  • thermoregulation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Coon, E., & Low, P. A. (2018). Thermoregulation in Parkinson disease. In Handbook of Clinical Neurology (pp. 715-725). (Handbook of Clinical Neurology; Vol. 157). Elsevier B.V.. https://doi.org/10.1016/B978-0-444-64074-1.00043-4

Thermoregulation in Parkinson disease. / Coon, Elizabeth; Low, Phillip Anson.

Handbook of Clinical Neurology. Elsevier B.V., 2018. p. 715-725 (Handbook of Clinical Neurology; Vol. 157).

Research output: Chapter in Book/Report/Conference proceedingChapter

Coon, E & Low, PA 2018, Thermoregulation in Parkinson disease. in Handbook of Clinical Neurology. Handbook of Clinical Neurology, vol. 157, Elsevier B.V., pp. 715-725. https://doi.org/10.1016/B978-0-444-64074-1.00043-4
Coon E, Low PA. Thermoregulation in Parkinson disease. In Handbook of Clinical Neurology. Elsevier B.V. 2018. p. 715-725. (Handbook of Clinical Neurology). https://doi.org/10.1016/B978-0-444-64074-1.00043-4
Coon, Elizabeth ; Low, Phillip Anson. / Thermoregulation in Parkinson disease. Handbook of Clinical Neurology. Elsevier B.V., 2018. pp. 715-725 (Handbook of Clinical Neurology).
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