Thermolabile Phenol Sulfotransferase Gene (STM): Localization to Human Chromosome 16p11.2

Ibrahim A. Aksoy, David F. Callen, Sinoula Apostolou, Chengtao Her, Richard M Weinshilboum

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Thermolabile (TL) phenol sulfotransferase (PST) catalyzes the sulfate conjugation of phenolic monoamine neurotransmitters such as dopamine and serotonin. We recently cloned a cDNA for human liver TL PST and expressed it in COS-1 cells. We now report the chromosomal localization of the human TL PST gene (STM) as well as its partial sequence. DNA from NIGMS Human/Rodent Somatic Cell Hybrid Mapping Panels 1 and 2 was screened by use of the PCR, and the STM gene was mapped to chromosome 16. Regional localization to 16p11.2 was performed by PCR analysis of a high-resolution mouse/human somatic cell hybrid panel that contained defined portions of human chromosome 16.

Original languageEnglish (US)
Pages (from-to)275-277
Number of pages3
JournalGenomics
Volume23
Issue number1
DOIs
StatePublished - Sep 1 1994

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Arylsulfotransferase
Human Chromosomes
Chromosomes, Human, Pair 16
Hybrid Cells
Genes
National Institute of General Medical Sciences (U.S.)
Polymerase Chain Reaction
COS Cells
Sulfates
Neurotransmitter Agents
Rodentia
Dopamine
Serotonin
Complementary DNA
Liver
DNA

ASJC Scopus subject areas

  • Genetics

Cite this

Thermolabile Phenol Sulfotransferase Gene (STM) : Localization to Human Chromosome 16p11.2. / Aksoy, Ibrahim A.; Callen, David F.; Apostolou, Sinoula; Her, Chengtao; Weinshilboum, Richard M.

In: Genomics, Vol. 23, No. 1, 01.09.1994, p. 275-277.

Research output: Contribution to journalArticle

Aksoy, Ibrahim A. ; Callen, David F. ; Apostolou, Sinoula ; Her, Chengtao ; Weinshilboum, Richard M. / Thermolabile Phenol Sulfotransferase Gene (STM) : Localization to Human Chromosome 16p11.2. In: Genomics. 1994 ; Vol. 23, No. 1. pp. 275-277.
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