Thermolabile phenol sulfotransferase gene (stm): Localization to human chromosome 16p11.2

Ibrahim A. Aksoy, David F. Callen, Sinoula Apostolou, Chengtao Her, Richard M. Weinshilboum

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Thermolabile (TL) phenol sulfotransferase (PST) catalyzes the sulfate conjugation of phenolic monoamine neurotransmitters such as dopamine and serotonin. We recently cloned a cDNA for human liver TL PST and expressed it in COS-1 cells. We now report the chromosomal localization of the human TL PST gene (STM) as well as its partial sequence. DNA from NIGMS Human/Rodent Somatic Cell Hybrid Mapping Panels 1 and 2 was screened by use of the PCR, and the STM gene was mapped to chromosome 16. Regional localization to 16p11.2 was performed by PCR analysis of a high-resolution mouse/human somatic cell hybrid panel that contained defined portions of human chromosome 16.

Original languageEnglish (US)
Pages (from-to)275-277
Number of pages3
JournalGenomics
Volume23
Issue number1
DOIs
StatePublished - Sep 1 1994

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Thermolabile phenol sulfotransferase gene (stm): Localization to human chromosome 16p11.2'. Together they form a unique fingerprint.

  • Cite this