Thermolabile phenol sulfotransferase gene (stm): Localization to human chromosome 16p11.2

Ibrahim A. Aksoy; David F. Callen; Sinoula Apostolou; Chengtao Her; Richard M. Weinshilboum

doi:10.1006/geno.1994.1494

Thermolabile phenol sulfotransferase gene (stm): Localization to human chromosome 16p11.2

Ibrahim A. Aksoy, David F. Callen, Sinoula Apostolou, Chengtao Her, Richard M. Weinshilboum

Pharmacology

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27 Scopus citations

Abstract

Thermolabile (TL) phenol sulfotransferase (PST) catalyzes the sulfate conjugation of phenolic monoamine neurotransmitters such as dopamine and serotonin. We recently cloned a cDNA for human liver TL PST and expressed it in COS-1 cells. We now report the chromosomal localization of the human TL PST gene (STM) as well as its partial sequence. DNA from NIGMS Human/Rodent Somatic Cell Hybrid Mapping Panels 1 and 2 was screened by use of the PCR, and the STM gene was mapped to chromosome 16. Regional localization to 16p11.2 was performed by PCR analysis of a high-resolution mouse/human somatic cell hybrid panel that contained defined portions of human chromosome 16.

Original language	English (US)
Pages (from-to)	275-277
Number of pages	3
Journal	Genomics
Volume	23
Issue number	1
DOIs	https://doi.org/10.1006/geno.1994.1494
State	Published - Sep 1 1994

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Genetics

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AU - Her, Chengtao

AU - Weinshilboum, Richard M.

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Thermolabile phenol sulfotransferase gene (stm): Localization to human chromosome 16p11.2

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