Therapy-related myeloid neoplasms

Carlos E. Bueso-Ramos, Rashmi Kanagal-Shamanna, Mark J. Routbort, Curtis A. Hanson

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Objectives: In the 2008 World Health Organization classification, cases of acute myeloid leukemia (AML) and myelodysplastic syndrome that arise after chemotherapy or radiation therapy for a primary neoplasm are considered together as therapy-related myeloid neoplasms (TR-MNs). This concept, however, is not universally accepted since there are confounding variables in attributing myeloid neoplasms to earlier therapies. Methods: Cases in session 6 of the 2013 Workshop of the Society for Hematopathology/European Association for Haematopathology illustrated myeloid neoplasms thought likely to be TR-MNs, and discussed the differences and biologic similarities with de novo myeloid neoplasms. Results: We reviewed data showing that diagnosis of TR-MN alters patient outcome only in specific subsets. The session also included examples of therapy-related AML with recurrent genetic abnormalities, such as t(15;17), inv(16), and t(8;21), and reports were highlighted showing that patients with these neoplasms have clinical outcomes similar to patients with their de novo counterparts. Conclusions: The study of TR-MNs will likely provide insight into the pathogenesis of de novo myeloid disease and may explain why some patients with cancer develop TR-MN and evidently have a higher genetic susceptibility, whereas most patients treated with the same agents do not. These studies will also result in critical reappraisal of current concepts related to TR-MNs.

Original languageEnglish (US)
Pages (from-to)207-218
Number of pages12
JournalAmerican journal of clinical pathology
Volume144
Issue number2
DOIs
StatePublished - Aug 2015

Keywords

  • Alkylating agents
  • Ionizing radiation therapy
  • Therapy-related acute myeloid leukemia
  • Therapy-related myelodysplastic syndrome
  • Therapy-related myeloid neoplasms
  • Topoisomerase II inhibitors

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Bueso-Ramos, C. E., Kanagal-Shamanna, R., Routbort, M. J., & Hanson, C. A. (2015). Therapy-related myeloid neoplasms. American journal of clinical pathology, 144(2), 207-218. https://doi.org/10.1309/AJCPU1JO2LYTWUAV