Therapy-related B lymphoblastic leukemia with t(4;11)(q21;q23)/AF4-MLL in a patient with mantle cell lymphoma after recent aggressive chemotherapy - A unique case report

Stephanie L. Holdener; Lacey Harrington; Johnny Nguyen; Pedro Horna; Elizabeth Sagatys; Bijal Shah; Ling Zhang

Therapy-related B lymphoblastic leukemia with t(4;11)(q21;q23)/AF4-MLL in a patient with mantle cell lymphoma after recent aggressive chemotherapy - A unique case report

Stephanie L. Holdener, Lacey Harrington, Johnny Nguyen, Pedro Horna, Elizabeth Sagatys, Bijal Shah, Ling Zhang

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Mantle cell lymphoma (MCL) is a mature B-cell lymphoma associated with the hallmark translocation t(11;14)(q13;32), which involves the cyclin D1 (CCND1) and immunoglobin heavy chain (IgH) genes. It may transform to a more aggressive blastoid or pleomorphic variant, with or without acquisition of chromosomal abnormalities. MCL could also present with a leukemic phase with marked lymphocytosis. A literature search did not reveal any prior reports of MCL transforming to or followed by a B-cell lymphoblastic leukemia (B-ALL).

Original language	English (US)
Pages (from-to)	1800-1804
Number of pages	5
Journal	International Journal of Clinical and Experimental Pathology
Volume	7
Issue number	4
State	Published - Jan 1 2014

Keywords

Lymphoma
Mantle
Therapy
Transformation
Variant

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology

Cite this

Therapy-related B lymphoblastic leukemia with t(4;11)(q21;q23)/AF4-MLL in a patient with mantle cell lymphoma after recent aggressive chemotherapy - A unique case report. / Holdener, Stephanie L.; Harrington, Lacey; Nguyen, Johnny et al.
In: International Journal of Clinical and Experimental Pathology, Vol. 7, No. 4, 01.01.2014, p. 1800-1804.

Research output: Contribution to journal › Article › peer-review

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Therapy-related B lymphoblastic leukemia with t(4;11)(q21;q23)/AF4-MLL in a patient with mantle cell lymphoma after recent aggressive chemotherapy - A unique case report

Abstract

Keywords

ASJC Scopus subject areas

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