Therapy-related B lymphoblastic leukemia with t(4;11)(q21;q23)/AF4-MLL in a patient with mantle cell lymphoma after recent aggressive chemotherapy - A unique case report

Stephanie L. Holdener, Lacey Harrington, Johnny Nguyen, Pedro Horna, Elizabeth Sagatys, Bijal Shah, Ling Zhang

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Mantle cell lymphoma (MCL) is a mature B-cell lymphoma associated with the hallmark translocation t(11;14)(q13;32), which involves the cyclin D1 (CCND1) and immunoglobin heavy chain (IgH) genes. It may transform to a more aggressive blastoid or pleomorphic variant, with or without acquisition of chromosomal abnormalities. MCL could also present with a leukemic phase with marked lymphocytosis. A literature search did not reveal any prior reports of MCL transforming to or followed by a B-cell lymphoblastic leukemia (B-ALL).

Original languageEnglish (US)
Pages (from-to)1800-1804
Number of pages5
JournalInternational Journal of Clinical and Experimental Pathology
Volume7
Issue number4
StatePublished - Jan 1 2014

Keywords

  • Lymphoma
  • Mantle
  • Therapy
  • Transformation
  • Variant

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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