Gentherapeutische ansatze in der arthrosebehandlung

Translated title of the contribution: Therapy of arthritis by gene transfer

H. D. Möller, Christopher H Evans

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Current concepts in treating arthritis by gene transfer are described, including different vector systems and strategies of gene transfer into target cells. Promising antiarthritic gene products are a variety of growth factors which facilitate increased matrix synthesis and mitogenesis in articular chondrocytes. Furthermore, rheumatoid joint destruction can be treated genetically by the transfer of certain antiinflammatory cytokine genes, which provide locally high concentrations of the antiinflammatory gene product. First clinical trails using the IRAP gene (interleukin I receptor antagonist protein) to eliminate the inflammatory reaction caused by interleukin I in rheumatoid joints are on its way. In order to investigate potential improvement in cartilage regeneration retroviral TGF-β gene transfer in rabbit articular chondrocytes has been carried out. The TGF-β group showed an in vitro increase in collagen type II neosynthesis by 304%, compared to normal chondrocytes.

Translated title of the contributionTherapy of arthritis by gene transfer
Original languageGerman
Pages (from-to)76-81
Number of pages6
JournalOrthopade
Volume28
Issue number1
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

Keywords

  • Articular cartilage
  • Gene transfer
  • Growth factors
  • Matrix synthesis

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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