Therapies for multiple sclerosis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Multiple sclerosis (MS) is an idiopathic inflammatory demyelinating disease of the central nervous system. It is one of the leading causes of neurologic disability, particularly in young adults, and is presumed to be autoimmune. This chapter discusses the evidence supporting the use of the MS therapies. It presents clinical scenarios for the following: clinically isolated syndrome, interferon-beta and glatiramer acetate for relapsing-remitting multiple sclerosis, natalizumab and fingolimod, teriflunomide and dimethyl fumarate, secondary progressive MS, primary progressive MS, and dalfampridine. Disease-modifying therapies are all effective for reducing the annual relapse rate of relapsing-remitting disease (RRMS). In summary, substantial progress has been made toward halting inflammatory disease activity in RRMS but future therapies will need to focus on SPMS and PPMS in order to meet the major unmet needs, particularly accumulation of neurological disability, of patients with multiple sclerosis.

Original languageEnglish (US)
Title of host publicationEvidence-Based Neurology
Subtitle of host publicationManagement of Neurological Disorders: Second Edition
PublisherWiley Blackwell
Pages209-218
Number of pages10
ISBN (Electronic)9781119067344
ISBN (Print)9780470657782
DOIs
StatePublished - Dec 11 2015

Keywords

  • Clinically isolated syndrome
  • Dalfampridine
  • Dimethyl fumarate
  • Fingolimod
  • Glatiramer acetate
  • Interferon-beta
  • Multiple sclerosis
  • Natalizumab
  • Teriflunomide

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Thaera, G., & Wingerchuk, D. M. (2015). Therapies for multiple sclerosis. In Evidence-Based Neurology: Management of Neurological Disorders: Second Edition (pp. 209-218). Wiley Blackwell. https://doi.org/10.1002/9781119067344.ch20