Therapeutic Value of Standard Versus Extended Pelvic Lymph Node Dissection During Radical Prostatectomy for High-Risk Prostate Cancer

Michele Colicchia, Vidit Sharma, Firas Abdollah, Alberto Briganti, Robert Jeffrey Karnes

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Extent of pelvic lymph node dissection (PLND) during radical prostatectomy (RP) remains a subject of debate. Here, we review the literature covering the value of extended PLND (ePLND) during RP for high-risk prostate cancer (PCa) over a standard PLND, with a focus on potential therapeutic advantage. PLND may provide valuable prognostic information to high-risk PCa patients, and incorporating the common iliac and presacral nodes to ePLND templates further improves pathologic nodal staging accuracy. Although increased PLND extent is associated with increased lymphocele/lymphedema rates, it is not associated with increased venous thromboembolism rates. The therapeutic role of ePLND remains uncertain. While recent retrospective studies suggest an increased number of nodes removed within the ePLND template are associated with improved survival outcomes, such retrospective studies cannot completely adjust for the Will Rodgers phenomenon or surgeon-specific factors. Thus, the results of randomized trials are eagerly awaited in this arena.

Original languageEnglish (US)
Article number51
JournalCurrent Urology Reports
Volume18
Issue number7
DOIs
StatePublished - Jul 1 2017

Fingerprint

Prostatectomy
Lymph Node Excision
Prostatic Neoplasms
Retrospective Studies
Lymphocele
Therapeutics
Lymphedema
Venous Thromboembolism
Survival

Keywords

  • Extended lymphadenectomy
  • Pelvic lymphadenectomy
  • Prostate cancer
  • Radical prostatectomy

ASJC Scopus subject areas

  • Urology

Cite this

Therapeutic Value of Standard Versus Extended Pelvic Lymph Node Dissection During Radical Prostatectomy for High-Risk Prostate Cancer. / Colicchia, Michele; Sharma, Vidit; Abdollah, Firas; Briganti, Alberto; Karnes, Robert Jeffrey.

In: Current Urology Reports, Vol. 18, No. 7, 51, 01.07.2017.

Research output: Contribution to journalReview article

@article{048ba8da099e42f7b6c6d1c832ac36c5,
title = "Therapeutic Value of Standard Versus Extended Pelvic Lymph Node Dissection During Radical Prostatectomy for High-Risk Prostate Cancer",
abstract = "Extent of pelvic lymph node dissection (PLND) during radical prostatectomy (RP) remains a subject of debate. Here, we review the literature covering the value of extended PLND (ePLND) during RP for high-risk prostate cancer (PCa) over a standard PLND, with a focus on potential therapeutic advantage. PLND may provide valuable prognostic information to high-risk PCa patients, and incorporating the common iliac and presacral nodes to ePLND templates further improves pathologic nodal staging accuracy. Although increased PLND extent is associated with increased lymphocele/lymphedema rates, it is not associated with increased venous thromboembolism rates. The therapeutic role of ePLND remains uncertain. While recent retrospective studies suggest an increased number of nodes removed within the ePLND template are associated with improved survival outcomes, such retrospective studies cannot completely adjust for the Will Rodgers phenomenon or surgeon-specific factors. Thus, the results of randomized trials are eagerly awaited in this arena.",
keywords = "Extended lymphadenectomy, Pelvic lymphadenectomy, Prostate cancer, Radical prostatectomy",
author = "Michele Colicchia and Vidit Sharma and Firas Abdollah and Alberto Briganti and Karnes, {Robert Jeffrey}",
year = "2017",
month = "7",
day = "1",
doi = "10.1007/s11934-017-0696-5",
language = "English (US)",
volume = "18",
journal = "Current Urology Reports",
issn = "1527-2737",
publisher = "Current Science, Inc.",
number = "7",

}

TY - JOUR

T1 - Therapeutic Value of Standard Versus Extended Pelvic Lymph Node Dissection During Radical Prostatectomy for High-Risk Prostate Cancer

AU - Colicchia, Michele

AU - Sharma, Vidit

AU - Abdollah, Firas

AU - Briganti, Alberto

AU - Karnes, Robert Jeffrey

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Extent of pelvic lymph node dissection (PLND) during radical prostatectomy (RP) remains a subject of debate. Here, we review the literature covering the value of extended PLND (ePLND) during RP for high-risk prostate cancer (PCa) over a standard PLND, with a focus on potential therapeutic advantage. PLND may provide valuable prognostic information to high-risk PCa patients, and incorporating the common iliac and presacral nodes to ePLND templates further improves pathologic nodal staging accuracy. Although increased PLND extent is associated with increased lymphocele/lymphedema rates, it is not associated with increased venous thromboembolism rates. The therapeutic role of ePLND remains uncertain. While recent retrospective studies suggest an increased number of nodes removed within the ePLND template are associated with improved survival outcomes, such retrospective studies cannot completely adjust for the Will Rodgers phenomenon or surgeon-specific factors. Thus, the results of randomized trials are eagerly awaited in this arena.

AB - Extent of pelvic lymph node dissection (PLND) during radical prostatectomy (RP) remains a subject of debate. Here, we review the literature covering the value of extended PLND (ePLND) during RP for high-risk prostate cancer (PCa) over a standard PLND, with a focus on potential therapeutic advantage. PLND may provide valuable prognostic information to high-risk PCa patients, and incorporating the common iliac and presacral nodes to ePLND templates further improves pathologic nodal staging accuracy. Although increased PLND extent is associated with increased lymphocele/lymphedema rates, it is not associated with increased venous thromboembolism rates. The therapeutic role of ePLND remains uncertain. While recent retrospective studies suggest an increased number of nodes removed within the ePLND template are associated with improved survival outcomes, such retrospective studies cannot completely adjust for the Will Rodgers phenomenon or surgeon-specific factors. Thus, the results of randomized trials are eagerly awaited in this arena.

KW - Extended lymphadenectomy

KW - Pelvic lymphadenectomy

KW - Prostate cancer

KW - Radical prostatectomy

UR - http://www.scopus.com/inward/record.url?scp=85020853770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020853770&partnerID=8YFLogxK

U2 - 10.1007/s11934-017-0696-5

DO - 10.1007/s11934-017-0696-5

M3 - Review article

VL - 18

JO - Current Urology Reports

JF - Current Urology Reports

SN - 1527-2737

IS - 7

M1 - 51

ER -