Therapeutic targeting strategies of cancer stem cells in gastrointestinal malignancies

Mohamad B. Sonbol, Daniel Ahn, Tanios Bekaii-Saab

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Cancer stem cells (CSCs) are thought to be a distinct population of cells within a tumor mass that are capable of asymmetric division and known to have chemoresistant characteristics. The description and identification of CSC models in cancer growth and recurrence has inspired the design of novel treatment strategies to overcome treatment resistance by targeting both CSCs and non-CSC tumor cells. Several cellular signaling pathways have been described as playing a role in the induction and maintenance of stemness in CSCs, such as the Wnt/β-catenin, Notch, STAT3, and Hedgehog pathways. In this review, we aim to review some of the ongoing CSC therapeutic targeting strategies in gastrointestinal malignancies.

Original languageEnglish (US)
Article number17
JournalBiomedicines
Volume7
Issue number1
DOIs
StatePublished - Mar 1 2019

Fingerprint

Neoplastic Stem Cells
Stem cells
Neoplasms
Tumors
Therapeutics
Cells
Cell signaling
Catenins
Identification (control systems)
Maintenance
Recurrence
Growth
Population

Keywords

  • BBI-608
  • cancer stem cell
  • Colorectal cancer
  • Gastric cancer
  • Napabucasin
  • Pancreatic cancer
  • STAT3
  • Wnt/β-catenin

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Therapeutic targeting strategies of cancer stem cells in gastrointestinal malignancies. / Sonbol, Mohamad B.; Ahn, Daniel; Bekaii-Saab, Tanios.

In: Biomedicines, Vol. 7, No. 1, 17, 01.03.2019.

Research output: Contribution to journalReview article

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