Therapeutic targeting strategies of cancer stem cells in gastrointestinal malignancies

Mohamad B. Sonbol, Daniel H. Ahn, Tanios Bekaii-Saab

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Cancer stem cells (CSCs) are thought to be a distinct population of cells within a tumor mass that are capable of asymmetric division and known to have chemoresistant characteristics. The description and identification of CSC models in cancer growth and recurrence has inspired the design of novel treatment strategies to overcome treatment resistance by targeting both CSCs and non-CSC tumor cells. Several cellular signaling pathways have been described as playing a role in the induction and maintenance of stemness in CSCs, such as the Wnt/β-catenin, Notch, STAT3, and Hedgehog pathways. In this review, we aim to review some of the ongoing CSC therapeutic targeting strategies in gastrointestinal malignancies.

Original languageEnglish (US)
Article number17
JournalBiomedicines
Volume7
Issue number1
DOIs
StatePublished - Mar 1 2019

Keywords

  • BBI-608
  • Colorectal cancer
  • Gastric cancer
  • Napabucasin
  • Pancreatic cancer
  • STAT3
  • Wnt/β-catenin
  • cancer stem cell

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)

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