Therapeutic targeting strategies of cancer stem cells in gastrointestinal malignancies

Mohamad B. Sonbol; Daniel H. Ahn; Tanios Bekaii-Saab

doi:10.3390/biomedicines7010017

Therapeutic targeting strategies of cancer stem cells in gastrointestinal malignancies

Mohamad B. Sonbol, Daniel H. Ahn, Tanios Bekaii-Saab

Hematology/Oncology

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Cancer stem cells (CSCs) are thought to be a distinct population of cells within a tumor mass that are capable of asymmetric division and known to have chemoresistant characteristics. The description and identification of CSC models in cancer growth and recurrence has inspired the design of novel treatment strategies to overcome treatment resistance by targeting both CSCs and non-CSC tumor cells. Several cellular signaling pathways have been described as playing a role in the induction and maintenance of stemness in CSCs, such as the Wnt/β-catenin, Notch, STAT3, and Hedgehog pathways. In this review, we aim to review some of the ongoing CSC therapeutic targeting strategies in gastrointestinal malignancies.

Original language	English (US)
Article number	17
Journal	Biomedicines
Volume	7
Issue number	1
DOIs	https://doi.org/10.3390/biomedicines7010017
State	Published - Mar 1 2019

Keywords

BBI-608
Colorectal cancer
Gastric cancer
Napabucasin
Pancreatic cancer
STAT3
Wnt/β-catenin
cancer stem cell

ASJC Scopus subject areas

Medicine (miscellaneous)
General Biochemistry, Genetics and Molecular Biology

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10.3390/biomedicines7010017

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title = "Therapeutic targeting strategies of cancer stem cells in gastrointestinal malignancies",

abstract = "Cancer stem cells (CSCs) are thought to be a distinct population of cells within a tumor mass that are capable of asymmetric division and known to have chemoresistant characteristics. The description and identification of CSC models in cancer growth and recurrence has inspired the design of novel treatment strategies to overcome treatment resistance by targeting both CSCs and non-CSC tumor cells. Several cellular signaling pathways have been described as playing a role in the induction and maintenance of stemness in CSCs, such as the Wnt/β-catenin, Notch, STAT3, and Hedgehog pathways. In this review, we aim to review some of the ongoing CSC therapeutic targeting strategies in gastrointestinal malignancies.",

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AU - Sonbol, Mohamad B.

AU - Ahn, Daniel H.

AU - Bekaii-Saab, Tanios

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Y1 - 2019/3/1

N2 - Cancer stem cells (CSCs) are thought to be a distinct population of cells within a tumor mass that are capable of asymmetric division and known to have chemoresistant characteristics. The description and identification of CSC models in cancer growth and recurrence has inspired the design of novel treatment strategies to overcome treatment resistance by targeting both CSCs and non-CSC tumor cells. Several cellular signaling pathways have been described as playing a role in the induction and maintenance of stemness in CSCs, such as the Wnt/β-catenin, Notch, STAT3, and Hedgehog pathways. In this review, we aim to review some of the ongoing CSC therapeutic targeting strategies in gastrointestinal malignancies.

AB - Cancer stem cells (CSCs) are thought to be a distinct population of cells within a tumor mass that are capable of asymmetric division and known to have chemoresistant characteristics. The description and identification of CSC models in cancer growth and recurrence has inspired the design of novel treatment strategies to overcome treatment resistance by targeting both CSCs and non-CSC tumor cells. Several cellular signaling pathways have been described as playing a role in the induction and maintenance of stemness in CSCs, such as the Wnt/β-catenin, Notch, STAT3, and Hedgehog pathways. In this review, we aim to review some of the ongoing CSC therapeutic targeting strategies in gastrointestinal malignancies.

KW - BBI-608

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KW - Gastric cancer

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KW - Pancreatic cancer

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Therapeutic targeting strategies of cancer stem cells in gastrointestinal malignancies

Abstract

Keywords

ASJC Scopus subject areas

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