Therapeutic potential of oncolytic measles virus: Promises and challenges

Research output: Contribution to journalReview article

46 Scopus citations

Abstract

Measles virus (MV) is a negative-strand RNA virus (paramyxovirus) with oncolytic properties. The significant preclinical activity of MV vaccine strains against a variety of tumor models, their potent bystander effect, their selectivity against tumor cells, and their ability to retain their oncolytic properties when engineered and retargeted makes them a promising oncolytic platform. In this article, we review potential applications and challenges associated with use of MV strains as cancer therapeutics.

Original languageEnglish (US)
Pages (from-to)620-625
Number of pages6
JournalClinical pharmacology and therapeutics
Volume88
Issue number5
DOIs
StatePublished - Nov 1 2010

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Therapeutic potential of oncolytic measles virus: Promises and challenges'. Together they form a unique fingerprint.

Cite this