Therapeutic potential for novel drugs targeting the type 1 cholecystokinin receptor

Erin E. Cawston, Laurence J. Miller

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Cholecystokinin (CCK) is a physiologically important gastrointestinal and neuronal peptide hormone, with roles in stimulating gallbladder contraction, pancreatic secretion, gastrointestinal motility and satiety. CCK exerts its effects via interactions with two structurally related class I guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs), the CCK 1 receptor and the CCK 2 receptor. Here, we focus on the CCK 1 receptor, with particular relevance to the broad spectrum of signalling initiated by activation with the natural full agonist peptide ligand, CCK. Distinct ligand-binding pockets have been defined for the natural peptide ligand and for some non-peptidyl small molecule ligands. While many CCK 1 receptor ligands have been developed and have had their pharmacology well described, their clinical potential has not yet been fully explored. The case is built for the potential importance of developing more selective partial agonists and allosteric modulators of this receptor that could have important roles in the treatment of common clinical syndromes.

Original languageEnglish (US)
Pages (from-to)1009-1021
Number of pages13
JournalBritish Journal of Pharmacology
Volume159
Issue number5
DOIs
StatePublished - Mar 2010

Keywords

  • CCK receptor agonists/antagonists/partial agonists
  • CCK receptor allosteric modulators
  • CCK receptor ligands/peptide/non-peptidyl
  • Cholecystokinin/physiology
  • Guanine nucleotide-binding protein-coupled receptors
  • Satiety/drug therapy/physiopathology
  • Type 1 cholecystokinin receptor

ASJC Scopus subject areas

  • Pharmacology

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