TY - JOUR
T1 - Therapeutic implications of leukemic stem cell pathways
AU - Chumsri, Saranya
AU - Matsui, William
AU - Burger, Angelika M.
PY - 2007/11/15
Y1 - 2007/11/15
N2 - An emerging concept in cancer biology is that a rare population of cancer stemcells exists among the heterogeneous cell mass that constitutes a tumor. This concept is best understood in human myeloid leukemia. Normal and malignant hematopoietic stem cell functions are defined by a common set of critical stemness genes that regulate self-renewal and developmental pathways. Several stemness factors, such as Notch or telomerase, show differential activation in normal hematopoietic versus leukemia stem cells. These differences could be exploited therapeutically even with drugs that are already in clinical use for the treatment of leukemia. The translation of novel and existing leukemic stem cell-directed therapies into clinical practice, however, will require changes in clinical trial design and the inclusion of stem cell biomarkers as correlative end points.
AB - An emerging concept in cancer biology is that a rare population of cancer stemcells exists among the heterogeneous cell mass that constitutes a tumor. This concept is best understood in human myeloid leukemia. Normal and malignant hematopoietic stem cell functions are defined by a common set of critical stemness genes that regulate self-renewal and developmental pathways. Several stemness factors, such as Notch or telomerase, show differential activation in normal hematopoietic versus leukemia stem cells. These differences could be exploited therapeutically even with drugs that are already in clinical use for the treatment of leukemia. The translation of novel and existing leukemic stem cell-directed therapies into clinical practice, however, will require changes in clinical trial design and the inclusion of stem cell biomarkers as correlative end points.
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U2 - 10.1158/1078-0432.CCR-07-1088
DO - 10.1158/1078-0432.CCR-07-1088
M3 - Review article
C2 - 18006753
AN - SCOPUS:36749027714
SN - 1078-0432
VL - 13
SP - 6549
EP - 6554
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 22
ER -