Therapeutic implications of leukemic stem cell pathways

Saranya Chumsri, William Matsui, Angelika M. Burger

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

An emerging concept in cancer biology is that a rare population of cancer stemcells exists among the heterogeneous cell mass that constitutes a tumor. This concept is best understood in human myeloid leukemia. Normal and malignant hematopoietic stem cell functions are defined by a common set of critical stemness genes that regulate self-renewal and developmental pathways. Several stemness factors, such as Notch or telomerase, show differential activation in normal hematopoietic versus leukemia stem cells. These differences could be exploited therapeutically even with drugs that are already in clinical use for the treatment of leukemia. The translation of novel and existing leukemic stem cell-directed therapies into clinical practice, however, will require changes in clinical trial design and the inclusion of stem cell biomarkers as correlative end points.

Original languageEnglish (US)
Pages (from-to)6549-6554
Number of pages6
JournalClinical Cancer Research
Volume13
Issue number22
DOIs
StatePublished - Nov 15 2007

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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